Quorum Sensing DB

Name	Kingdom	Phylum	Class	Order	Family	Genus	Species	Subspecies	Strain	Signal Class	QS Signal	PubChem CID	Sensing	Rel. Response	Evidence Sensing	Reference Sensing	Producing	Rel. Levels	Evidence Producing	Reference Producing	Quenching	Reference Quorum Quenching	Enzyme	Sequence ID Enzyme	Enzymatic Activity	Reference Enzymatic Activity	Evidence Activity	Sequence Identity (%) of Enzyme	to Query Sequence ID Enzyme	Location of Enzyme (Cellular/Extracellular)	Reference for Location	Synthase	Status Synthase	Reference Synthase	Sequence ID Synthase	Sequence Identity (%) Synthase	to query Sequence ID Synthase	Receptor	Status Receptor	Reference Receptor	Sequence ID Receptor	Sequence identity (%) Receptor	to query Sequence ID Receptor	Location Receptor	Reference	Effects 1	Reference Effects 1	Effects 2	Reference Effects 2	Effects 3	Reference Effects 3	Effects 4	Reference Effects 4	Effects 5	Reference Effects 5
Achromobacter xylosoxidans	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Alcaligenaceae	Achromobacter	xylosoxidans		NFRI-A1		PQS	2763159									YES	PubMed 25809238	unknown							?
Acinetobacter baumanii	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter	baumanii		M2	N-Acyl homoserine lactone	3-OH-C12-HSL	11507677	Yes?		Experimental	PubMed 18281398	Yes	major	Experimental	PubMed 18281398			HacB	WP_003160937.1								AbaI		PubMed 18281398	EU334497.1	33	AAA89074.1	AbaR	proposed	PubMed 18281398,PubMed PMID:20846031	B0FLN1.1	80	NP_416426.1	cytoplasm	PubMed 11700290	decreased biofilm formation	PubMed 18281398
Acinetobacter baumanii	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter	baumanii		M2	N-Acyl homoserine lactone	C10-HSL	10131281	Yes?				Yes	minor	Experimental	PubMed 18281398			AiiA	AF350935.1								AbaI		PubMed 18281398	EU334497.1	33	AAA89074.1	AbaR	proposed	PubMed 18281398,PubMed PMID:20846031	B0FLN1.1	80	NP_416426.1	cytoplasm	PubMed 11700290
Acinetobacter baumanii	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter	baumanii		M2	N-Acyl homoserine lactone	C12-HSL	11565426	Yes?				Yes	minor	Experimental	PubMed 18281398			AiiA	not known								AbaI		PubMed 18281398	EU334497.1	33	AAA89074.1	AbaR	proposed	PubMed 18281398,PubMed PMID:20846031	B0FLN1.1	80	NP_416426.1	cytoplasm	PubMed 11700290
Acinetobacter baumanii	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter	baumanii		S	N-Acyl homoserine lactone	3-OH-C12-HSL	11507677	"Yes"		Experimental	PubMed 28487993	Yes		Experimental	PubMed 28487993			AiiA	AF397400.1								AbaI		PubMed 28487993	no entry			?								decreased antibiotic sensitivity	PubMed 28487993
Acinetobacter calcoaceticus	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter	calcoaceticus		RUH0584	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Yes?			PubMed 22847269	Yes		no mutant	PubMed 22847269												LuxI	proposed	PubMed 22847269	no entry			LuxR	proposed	PubMed 22847269	KJH63785.1	27	NP_416426.1	cytoplasm	PubMed 11700290
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S1	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		Experimental	PubMed 22815678			AiiA	not known								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S11	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		Experimental	PubMed 22815678			PPH	ACF57854.1								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S54	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		Experimental	PubMed 22815678			PPH	ACF57854.1								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S93	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		Experimental	PubMed 22815678			PPH	ACF57854.1								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S117	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		Experimental	PubMed 22815678			unknown									AbaI		PubMed 22815678	no entry			?								required for efficient biofilm formation	PubMed 22815678
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S53	N-Acyl homoserine lactone	C12-HSL	11565426	?				Yes		Experimental	PubMed 22815678			AiiA	not known								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			S102	N-Acyl homoserine lactone	C12-HSL	11565426	?				Yes		Experimental	PubMed 22815678			AiiA	not known								AbaI		PubMed 22815678	no entry			?
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			GG2	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Yes?				Yes	minor	Experimental	PubMed 25926817			AiiA	not known								AciI		PubMed 25926817	no entry			AbaR	proposed	PubMed 25926817	WP_019456764.1	24	NP_416426.1	cytoplasm	PubMed 11700290
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			GG2	N-Acyl homoserine lactone	3-OH-C12-HSL	11507677	Yes?				Yes	major	Experimental	PubMed 25926817			AiiA	not known								AciI		PubMed 25926817	no entry			AbaR	proposed	PubMed 25926817	WP_019456764.1	24	NP_416426.1	cytoplasm	PubMed 11700290
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			C1010		C18-HSL	69757690									YES	PubMed 15644910	unknown				Predicted			cellular	PubMed 15644910
Acinetobacter spp	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Acinetobacter			C1010		C6-HSL	10058590									YES	PubMed 15644910	unknown				Predicted			cellular	PubMed 15644910
Actinomyces naeslundii	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Actinomycetaceae	Actinomyces	naeslundii		T14V	AI-2	AI-2	446576	"Yes"				Yes		no mutant	PubMed 16796680												LuxS		PubMed 16796680	OMG20629.1	38	QEH48503.1	?								increased biofilm formation	PubMed 16796680
Actinomyces odontolyticus subspecies actinosynbacter	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Actinomycetaceae	Actinomyces	odontolyticus subspecies actinosynbacter		XH001	AI-2	AI-2	446576	Yes?			PubMed 30319555	Yes		Experimental	PubMed 30319555												LuxS		PubMed 30319555	WP_060566748.1	39	QEH48503.1	LrsB	LrsB transcripts correlated with AI-2 concentration	PubMed 30319555	KSW13249.1	22	AYO33928.1	periplasm	PubMed 30319555	enhanced biofilm formation when associated with TM7x (Saccharibacteria)	PubMed 30319555
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		A1	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		Experimental	PubMed 9286976	Yes	major	Experimental	PubMed 9286976			QuiP	AAG04421.1								AhyI		PubMed 9286976	CAA61653.1	31	NP_250123.1	AhyR	proposed	PubMed 9286976	CAA61654.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		A1	N-Acyl homoserine lactone	C6-HSL	10058590	?				Yes	minor	Experimental	PubMed 9286976			QuiP	AAG04421.1								?						?
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		A1	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	Inhibit	-0.5	Experimental	PubMed 9286976	No		Experimental	PubMed 9286976			QuiP	AAG04421.1														?								inhibition of exoprotease production	PubMed 9286976
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		AH-1N	N-Acyl homoserine lactone	C4-HSL	10130163	"Yes"		Experimental	PubMed 10496895	Yes		Experimental	PubMed 10496895,PubMed PMID:15556717			PvdQ	NP_251075.1								AhyI		PubMed 10496895	X89469.1	31	NP_250123.1	AhyR	knockout resulted in reduced exoprotease production, no restoration with external C4-HSL, no significant reduction in AHL production	PubMed 10496895	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290	induced exoprotease production	PubMed 10496895
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		AH-1N	N-Acyl homoserine lactone	C10-HSL	10131281	Inhibit	-0.9	Experimental	PubMed 10496895	No			PubMed 10496895			PvdQ	NP_251075.1														AhyR	proposed	PubMed 10496895	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		AH-1N	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Inhibit	-1	Experimental	PubMed 10496895	No			PubMed 10496895			PvdQ	NP_251075.1														AhyR	proposed	PubMed 10496895	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		AH-1N	N-Acyl homoserine lactone	3-oxo-C14-HSL	9883786	Inhibit	-1	Experimental	PubMed 10496895	No			PubMed 10496895			PvdQ	NP_251075.1														AhyR	proposed	PubMed 10496895	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		SSU	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 18930130												LuxS		PubMed 18930130	EU499388.1	73	QEH48503.1	No		PubMed 18930130						increased motility	PubMed 18930130	decreased virulence in mouse infection model	PubMed 18930130
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hydrophila		not known	Indole	indole	798	?				Yes		no mutant	PubMed 457260												?						?
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C10-HSL	10131281	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C12-HSL	11565426	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		HX-3	N-Acyl homoserine lactone	C14-HSL	4534674	Yes?				Yes		no mutant	PubMed 32050067												AhyI		PubMed 32050067	MN241448.1	31	NP_250123.1	AhyR	proposed	PubMed 32050067	X89469.1	31	NP_416426.1	cytoplasm	PubMed 11700290
Aeromonas hydrophila	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	hyrophila		YZ2	N-Acyl homoserine lactone	C4-HSL	10130163	?				Yes?			PubMed 29868511												AhyI	proposed	PubMed 29868511	ABD59318.1	31	NP_250123.1	?
Aeromonas punctata	Bacteria	Proteobacteria	Gammaproteobacteria	Aeromonadales	Aeromonadaceae	Aeromonas	punctata		human isolate	Indole	indole	798	?				Yes		no mutant	PubMed 6029837												?						?
Aggregatibacter actinomycetemcomitans	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Aggregatibacter	actinomycetemcomitans		JP2	AI-2	AI-2	446576	Yes		Experimental	PubMed 17526716	Yes		Experimental	PubMed 17591788												LuxS		PubMed 17591788	QEH48503.1	100	QEH48503.1	LsrB/RbsB	knockout of LsrB and RbsB abolished AI-2 removal from extracellular environment	PubMed 17526716	WP_061885781.1/ TYB26582.1	27(LsrB); 87 (RbsB)	AYO33928.1	periplasm	PubMed 16790775	activation of biofilm formation	PubMed 22778662
Aggregatibacter actinomycetemcomitans	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Aggregatibacter	actinomycetemcomitans		serotype b (clinical isolate)	AI-2	AI-2	446576	Yes		Experimental	PubMed 17526716	Yes		Experimental	PubMed 25101248												LuxS		PubMed 25101248	QEH48503.1	100	QEH48503.1	LsrB/RbsB	knockout of LsrB and RbsB abolished AI-2 removal from extracellular environment	PubMed 17526716	WP_061885781.1/ TYB26582.1	27(LsrB); 87 (RbsB)	AYO33928.1	periplasm	PubMed 16790775	inhibited Candida albicans biofilm formation	PubMed 25101248
Bacillus alvei	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	alvei		ATCC 6348	Indole	indole	798	?				Yes		no mutant	PubMed 16562055												Tryptophanase		PubMed 16562055	WP_021261101.1	51	AMH37037.1	?
Bacillus anthracis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	anthracis		vaccine strain 34F2	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 12819077												LuxS		PubMed 12819077	WP_001141372.1	39	QEH48503.1	?								increased growth of strain	PubMed 12819077
Bacillus anthracis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	anthracis		Sterne	PapR	MKKLLIGSLLTLAMAWGISLGDTALEKNQVISHNDQEVQLASDVPFEY	none	Yes?				Yes?			PubMed 12198157												?						PlcR	proposed	PubMed 12198157	WP_000734728.1		not comparable	cytoplasm	PubMed 26344899	predicted to regulate hemolysis in insect larvae	PubMed 12198157	predicted to regulate virulence in insect larvae	PubMed 12198157
Bacillus anthracis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	anthracis		A2012	PhrA	?		Yes			PubMed 16385039	Yes?			PubMed 16385039												?						RapA	knockout of 20 aa of PhrA resulted in elimination of inhibition of phosphatase activity	PubMed 16385039	WP_187954324.1		not comparable	cytoplasm	PubMed 9238025	initiated sporulation	PubMed 16385039
Bacillus anthracis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	anthracis		Sterne	NprX/AqsP	?		Yes			PubMed 26344899	Yes?			PubMed 26344899												?						NprR/AqsR	knockout altered extracellular protease production, confimed by crystal structure	PubMed 26344899,PubMed PMID:21205011	WP_001187957.1		not comparable	cytoplasm	PubMed 26344899	regulated extracellular protease production	PubMed 26344899,21205011	required for survival and/or proliferation of Bacillus anthracis during anthrax pathogenesis	PubMed 26344899
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		ATCC 10987	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 16391139												LuxS		PubMed 16391139	AAS43847.1	40	QEH48503.1	LsrB	proposed	PubMed 16391139	AAS41923.1	23	AYO33928.1	periplasm	PubMed 16391139	decreased biofilm formation	PubMed 16391139
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		ATCC 14579	PapR	MKKLLIGSLLTLAMAWGISLGDTALEKSHIISHNDQEVQLAKDLPFEY	none	Yes?				Yes?			PubMed 12198157												?						PlcR	proposed	PubMed 12198157	WP_000734728.1		not comparable	cytoplasm	PubMed 26344899	predicted to regulate hemolysis in insect larvae	PubMed 12198157	predicted to regulate virulence in insect larvae	PubMed 12198157
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		30b		C4-HSL	10130163									YES	PubMed 31239733	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31239733	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		30b		C6-HSL	10058590									YES	PubMed 31239733	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31239733	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		30b		C10-HSL	10131281									YES	PubMed 31239733	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31239733	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		30b		3-oxo-C10-HSL	10221060									YES	PubMed 31239733	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31239733	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		30b		3-oxo-C12-HSL	3246941									YES	PubMed 31239733	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31239733	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		B25		3-oxo-C6-HSL	688505									YES	PubMed 11916693	AiiA	AF350935.1	N-acyl-homoserine lactonase	PubMed 11916693	Predicted	32	AAO47340.1	?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		ATCC 14579		3-oxo-C6-HSL	688505									YES	PubMed 11916693	AiiA	not known	N-acyl-homoserine lactonase	PubMed 11916693	Predicted			?
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		A24		C4-HSL	10130163									YES	PubMed 11932439	AiiA	AF397400.1	N-acyl-homoserine lactonase	PubMed 11932439	Predicted	32	AAO47340.1	cellular	PubMed 11932439
Bacillus cereus	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	cereus		A23		C4-HSL	10130163									YES	PubMed 11932439	AiiA	not known	N-acyl-homoserine lactonase	PubMed 11932439	Predicted			cellular	PubMed 11932439
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		168	AI-2	AI-2	446576	Yes		Experimental	PubMed 33097715	Yes?			PubMed 33097715,PubMed PMID:18803868												LuxS		PubMed 18803868	NP_390945.1	38	QEH48503.1	KinD	confirmed by heterologous expression and in vitro kinase assay	PubMed 33097715	QJF44894.1		not comparable	membrane	PubMed 33097715	regulated biofilm production	PubMed 21622736
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		NCIB 3610	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 26779171												LuxS		PubMed 26779171	AGG62471.1	38	QEH48503.1	No		PubMed 18803868						essential for biofilm formation	PubMed 26779171
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		168	ComX	ADPITRQ(W)GD	none	Yes		Experimental	PubMed 8168130	Yes		Experimental	PubMed 8168130												ComQ		PubMed 8168130,PubMed PMID:11751817	CAB07902.1	100	CAB07902.1	ComP	knockout mutant didn't respond to added partially purified ComX pheromone	PubMed 8168130	AIC41638.1	100	AIC41638.1	membrane	PubMed 10419951	required for genetic competence	PubMed 11751817
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		JH642	PhrA	ARNQT	none	Yes		Experimental	PubMed 9238025,PMID:8643670	Yes		Experimental	PubMed 9238025,PMID:8643670												?						RapA	phrA gene deletion led to uncontrolled RapA phosphatase activity which led to no initiation of sporulation	PubMed 9238025,PMID:8643670	AIC39638.1		not comparable	cytoplasm	PubMed 9238025	initiated sporulation	PubMed 9238025,PMID:8643670
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		JH642	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 16740951												LuxS		PubMed 16740951	AIC41532.1	38	QEH48503.1	LsrB	proposed	PubMed 16740951	no entry
Bacillus subtilis	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis		PS-216	ComX	ADPITRQ(W)GD	none	Yes?				Yes		Experimental	PubMed 32727033												ComQ		PubMed 32727033	ACJ67479.2	100	CAB07902.1	ComP	proposed	PubMed 32727033	AFJ78996.1	100	AIC41638.1	membrane	PubMed 32727033	affected sporulation positively	PubMed 32727033	affected biofilm formation negatively	PubMed 32727033	required for the activation of extracellular degradative enzyme production	PubMed 32727033
Bacillus subtilis (natto)	Bacteria	Firmicutes	Bacilli	Bacillales	Bacillaceae	Bacillus	subtilis (natto)		RG4365	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 16740951												LuxS		PubMed 16740951	BAI86580.1	38	QEH48503.1	LsrB	proposed	PubMed 16740951	no entry					required to form biofilms	PubMed 16740951	required to swarm	PubMed 16740951
Bacteroides fragilis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	fragilis		ATCC 25285	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?			PubMed 18188535	No			PubMed 18188535			AiiA	not known														LuxR	proposed	PubMed 18188535	SUV38279.1	34	AAN52499.1	cytoplasm	PubMed 11700290	increased biofilm formation	PubMed 18188535
Bacteroides fragilis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	fragilis		B3b	AI-2	AI-2	446576	?				Yes		Experimental	PubMed 24026770												LuxS		PubMed 24026770	no entry			?
Bacteroides thetaiotaomicron	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	thetaiotaomicron		mouse isolate	Indole	indole	798	?				Yes		no mutant	PubMed 869524												?						?
Bacteroides vulgatus	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	vulgatus		ATCC 8482	AI-2	AI-2	446576	?				Yes		Experimental	PubMed 24026770												LuxS		PubMed 24026770	ABR38590.1	29	QEH48503.1	?
Bifidobacterium longum	Bacteria	Actinobacteria	Actinobacteria	Bifidobacteriales	Bifidobacteriaceae	Bifidobacterium	longum		NCC2705	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 24505453												LuxS		PubMed 24505453	AAN24957.1	37	QEH48503.1	No		PubMed 18803868						increased biofilm formation	PubMed 24505453
Burkholderia cenocepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cenocepacia		K56-2	N-Acyl homoserine lactone	C8-HSL	6914579	Yes		Experimental	PubMed 9922236	Yes		Experimental	PubMed 9922236												CepI		PubMed 9922236	AF019654.1	44	AAA89074.1	CepR	knockout effect on ornibactin and protease production was restored with external AHL	PubMed 9922236	AF019654.1	34	NP_416426.1	cytoplasm	PubMed 11700290	upregulation of lipase activity	PubMed 9922236	downregulation of siderophore ornibactin production	PubMed 9922236
Burkholderia cenocepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cenocepacia		H111	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?		proposed	PubMed 11535791	Yes	minor	Experimental	PubMed 11403388												CepI		PubMed 11403388	AF330014.1	44	AAA89074.1	CepR	proposed	PubMed 11403388	AF330020.1	35	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia cenocepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cenocepacia		H111	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?		proposed	PubMed 11535791	Yes	major	Experimental	PubMed 11403388												CepI		PubMed 11403388	AF330014.1	44	AAA89074.1	CepR	proposed	PubMed 11403388	AF330020.1	35	NP_416426.1	cytoplasm	PubMed 11700290	increased chitinase production	PubMed 11535791	increased proteolytic activity	PubMed 11535791	increased siderophore production	PubMed 11535791	increased swarming motility	PubMed 11535791	increased biofilm formation	PubMed 11535791
Burkholderia cenocepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cenocepacia		K56-2	N-Acyl homoserine lactone	C8-HSL	6914579	Inhibit			PubMed 23136852	Yes		Experimental	PubMed 23136852												CepI		PubMed 23136852	AF019654.1	44	AAA89074.1	CepR2	cepR2 mutant overexpressed a cluster of linked genes, which were also upregulated by C8-HSL in the wildtype	PubMed 23136852	no entry			cytoplasm	PubMed 11700290
Burkholderia cepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cepacia		CEP 509	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?		proposed	PubMed 11402012	Yes	minor	no mutant	PubMed 11402012												CepI	proposed	PubMed 11402012	AAD12727.1	44	AAA89074.1	CepR	proposed	PubMed 11402012	AAD12726.1	34	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia cepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cepacia		CEP 509	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?		proposed	PubMed 11402012	Yes	major	no mutant	PubMed 11402012												CepI	proposed	PubMed 11402012	AAD12727.1	44	AAA89074.1	CepR	proposed	PubMed 11402012	AAD12726.1	34	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia cepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cepacia		ATCC 25416	N-Acyl homoserine lactone	C6-HSL	10058590	Yes	1	Experimental	PubMed 12620866	Yes		Experimental	PubMed 12620866												CepI		PubMed 12620866	AJ422183.1	44	AAA89074.1	CepR	knockout decreased AHL production, cepR-PcepI-lacZ fusion was activated by AHL	PubMed 12620866	AJ422183.1	36	NP_416426.1	cytoplasm	PubMed 11700290	increased maceration of Allium cepa onion due to decrease in production of extracellular polygalacturonase	PubMed 12620866	increased proteolytic activity	PubMed 12620866
Burkholderia cepacia	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	cepacia		ATCC 25416	N-Acyl homoserine lactone	C8-HSL	6914579	Yes	0.15	Experimental	PubMed 12620866	Yes		Experimental	PubMed 12620866												CepI		PubMed 12620866	AJ422183.1	44	AAA89074.1	CepR	knockout decreased AHL production, cepR-PcepI-lacZ fusion was activated by AHL	PubMed 12620866	AJ422183.1	36	NP_416426.1	cytoplasm	PubMed 11700290	increased maceration of Allium cepa onion due to decrease in production of extracellular polygalacturonase	PubMed 12620866	increased proteolytic activity	PubMed 12620866
Burkholderia multivorans	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	multivorans		C5393	N-Acyl homoserine lactone	C8-HSL	6914579	?				Yes		no mutant	PubMed 11402012												?						?
Burkholderia multivorans	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	multivorans		C5393	N-Acyl homoserine lactone	C6-HSL	10058590	?				Yes		no mutant	PubMed 11402012												?						?
Burkholderia multivorans	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	multivorans		LMG 13010	N-Acyl homoserine lactone	?		Yes?			PubMed 11402012	?															?						CepR	proposed	PubMed 11402012	AF333004.1	35	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		KHW	N-Acyl homoserine lactone	C8-HSL	6914579	Yes		Experimental	PubMed 15629951	Yes		Experimental	PubMed 15629951												BpsI		PubMed 15629951	AY373337.1	45	AAA89074.1	BpsR	knockout abolished cell-density dependent expression of bpsI	PubMed 15629951	AY373337.1	35	NP_416426.1	cytoplasm	PubMed 11700290	increased virulence in Caenorhabditis elegans infection model	PubMed 15629951
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	C8-HSL	6914579	Yes		Experimental	PubMed 17159218	Yes		Experimental	PubMed 17159218												BpsI		PubMed 17159218	AF501236.2	44	AAA89074.1	BpsR	knockout abolished synthesis of AHL	PubMed 17159218	AF501236.2	34	NP_416426.1	cytoplasm	PubMed 11700290	increased ?-galactosidase activity	PubMed 17159218
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes		Experimental	PubMed 17159218	Yes		Experimental	PubMed 17159218												BpsI		PubMed 17159218	AF501236.2	44	AAA89074.1	BpsR	knockout abolished synthesis of AHL	PubMed 17159218	AF501236.2	34	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	3-OH-C8-HSL	274418323	?				Yes		no mutant	PubMed 17159218												?						?
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		no mutant	PubMed 17159218												?						?
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	3-OH-C10-HSL	71353010	?				Yes		no mutant	PubMed 17159218												?						?
Burkholderia pseudomallei (KHW)	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	pseudomallei		PP844	N-Acyl homoserine lactone	3-OH-C12-HSL	11507677	?				Yes		no mutant	PubMed 17159218												?						?
Burkholderia stabilis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	stabilis		LMG 14294	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?				Yes		no mutant	PubMed 11402012												CepI		PubMed 11402012	AAK70351.1	45	AAA89074.1	CepR	proposed	PubMed 11402012	AAK70350.1	35	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia vietnamiensis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	vietnamiensis		G4	N-Acyl homoserine lactone	C10-HSL	10131281	Yes		Experimental	PubMed 17277056	Yes		Experimental	PubMed 17277056												BviI		PubMed 17277056	EF032807.1	37	AAA89074.1	BviR		PubMed 17277056	EF032807.1	32	NP_416426.1	cytoplasm	PubMed 11700290	increased antibiotic production	PubMed 17277056
Burkholderia vietnamiensis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	vietnamiensis		G4	N-Acyl homoserine lactone	C12-HSL	11565426	Yes				Yes		Experimental	PubMed 11807080												BviI		PubMed 11807080	EF032807.1	37	AAA89074.1	BviR	knockout abolished AHL production	PubMed 11807080	EF032807.1	32	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia vietnamiensis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	vietnamiensis		G4	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	Yes				Yes		Experimental	PubMed 11807080												BviI		PubMed 11807080	EF032807.1	37	AAA89074.1	BviR	knockout abolished AHL production	PubMed 11807080	EF032807.1	32	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia vietnamiensis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	vietnamiensis		G4	N-Acyl homoserine lactone	C6-HSL	10058590	Yes			PubMed 17277056	Yes		Experimental	PubMed 17277056												CepI		PubMed 17277056	EF212890.1	37	AAA89074.1	CepR		PubMed 17277056	EF032807.1	32	NP_416426.1	cytoplasm	PubMed 11700290
Burkholderia vietnamiensis	Bacteria	Proteobacteria	Betaproteobacteria	Burkholderiales	Burkholderiaceae	Burkholderia	vietnamiensis		G4	N-Acyl homoserine lactone	C8-HSL	6914579	Yes			PubMed 17277056	Yes		Experimental	PubMed 17277056												CepI		PubMed 17277056	EF212890.1	37	AAA89074.1	CepR		PubMed 17277056	EF032807.1	32	NP_416426.1	cytoplasm	PubMed 11700290
Butyriviberio fibrosolvens	Bacteria	Firmicutes	Clostridia	Clostridiales	Lachnospiraceae	Butyriviberio	fibrosolvens		ATCC 19171T	AI-2	AI-2	446576	?				Yes		Experimental	PubMed 12594022												LuxS		PubMed 12594022	SEQ96597.1	32	QEH48503.1	?
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	C4-HSL	10130163	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								increased the transition rate to VBNC state	PubMed 21205102	upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	C6-HSL	10058590	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	C8-HSL	6914579	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	C10-HSL	10131281	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	C12-HSL	11565426	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		81-176	N-Acyl homoserine lactone	3-OH-C4-HSL	10330086	"Yes"		Experimental	PubMed 21205102	No			PubMed 11988522																		?								increased the transition rate to VBNC state	PubMed 21205102	inhibited biofilm formation	PubMed 21205102	upregulation of virulence determinant genes	PubMed 21205102
Campylobacter jejuni	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	jejuni		NCTC 11168	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 11988522												LuxS			CAL35313.1	71	QEH48503.1	?								regulated motility	PubMed 11988522
Campylobacter sputorum	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Campylobacteraceae	Campylobacter	sputorum		CCUG 37580	AI-2	AI-2	446576	No				Yes		no mutant	PubMed 22188245												LuxS		PubMed 22188245	ASM40037.1	69	QEH48503.1	No
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		SC5314	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Inhibit		Experimental	PubMed 15554963	No			PubMed 15554963																		Inhibit								inhibition of filamentation	PubMed 15554963
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		SC5314	N-Acyl homoserine lactone	C12-HSL	11565426	Inhibit		Experimental	PubMed 15554963	No			PubMed 15554963																		Inhibit								inhibition of filamentation	PubMed 15554963
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		ATCC10231	AI-2	AI-2	446576	Inhibit		Experimental	PubMed 25101248	No			PubMed 25101248																		Inhibit								inhibited hypha formation	PubMed 25101248	inhibited biofilm formation	PubMed 25101248
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		DAY185	Indole	indole	798	"Yes"				No			PubMed 22726313																		?								reduced biofilm formation	PubMed 22726313	attenuated virulence	PubMed 22726313
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		A-72	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		MEN	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		SG 5314	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		LGH 1095	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		SG 3314	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Candida albicans	Fungi	Ascomycota	Saccharomycetes	Saccharomycetales	Saccharomycetaceae	Candida	albicans		SG 10261	Farnesol	farnesol	445070	"Yes"			PubMed 11425711	Yes			PubMed 11425711												?						?								prevented yeast-to-mycelium conversion	PubMed 11425711
Capnocytophaga ochracea	Bacteria	Bacteroidetes	Flavobacteria	Flavobacteriales	Flavobacteriaceae	Capnocytophaga	ochracea		ATCC 27872	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 26800339												LuxS		PubMed 26800339	SQA78472.1	30	QEH48503.1	?								increased biofilm formation	PubMed 26800339
Capnocytophaga sputigena	Bacteria	Bacteroidetes	Flavobacteria	Flavobacteriales	Flavobacteriaceae	Capnocytophaga	sputigena		not known	AI-2	AI-2	446576	?				Yes?			PubMed 20331790												LuxS		PubMed 20331790	SQA75583.1	30	QEH48503.1	?
Citrobacter amalonaticus	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	amalonaticus		L8A	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		proposed		Yes		no mutant	PubMed 26860259												CroI	proposed	PubMed 26860259	KEY50943.1	39	X76082.1	LuxR	proposed	PubMed 26860259	KEY50952.1	28	AAN52499.1	cytoplasm	PubMed 11700290
Citrobacter amalonaticus	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	amalonaticus		L8A	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?		proposed		Yes		no mutant	PubMed 26860259												CroI	proposed	PubMed 26860259	KEY50943.1	39	X76082.1	LuxR	proposed	PubMed 26860259	KEY50952.1	28	AAN52499.1	cytoplasm	PubMed 11700290
Citrobacter amalonaticus	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	amalonaticus		L8A	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?		proposed		Yes		no mutant	PubMed 26860259												CroI	proposed	PubMed 26860259	KEY50943.1	39	X76082.1	LuxR	proposed	PubMed 26860259	KEY50952.1	28	AAN52499.1	cytoplasm	PubMed 11700290
Citrobacter amalonaticus	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	amalonaticus		L8A	N-Acyl homoserine lactone	C16-HSL	11609787	Yes?		proposed		Yes		no mutant	PubMed 26860259												CroI	proposed	PubMed 26860259	KEY50943.1	39	X76082.1	LuxR	proposed	PubMed 26860259	KEY50952.1	28	AAN52499.1	cytoplasm	PubMed 11700290
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		ST2	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?				Yes		no mutant	PubMed 27807655												?						LuxR	proposed	PubMed 26697383	not consistent			cytoplasm	PubMed 11700290
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		ST2	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?				Yes		no mutant	PubMed 27807655												?						LuxR	proposed	PubMed 26697383	not consistent			cytoplasm	PubMed 11700290
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		ST2	N-Acyl homoserine lactone	C10-HSL	10131281	Yes?				Yes		no mutant	PubMed 27807655												?						LuxR	proposed	PubMed 26697383	not consistent			cytoplasm	PubMed 11700290
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		SRRSH27	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	?				Yes		no mutant	PubMed 17108283												?						?
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		SRRSH27	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	?				Yes		no mutant	PubMed 17108283												?						?
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		ST2	AI-2	AI-2	446576	?				Yes?			PubMed 26697383												LuxS		PubMed 26697383	KEL78527.1	71	QEH48503.1	?
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		NCTC 6266	Indole	indole	798	?				Yes		no mutant	PubMed 4496972												?						?
Citrobacter freundii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	freundii		NCTC 6071	Indole	indole	798	?				Yes		no mutant	PubMed 4496972												?						?
Citrobacter koseri	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	koseri		NCTC 10769	Indole	indole	798	?				Yes		no mutant	PubMed 4496972												?						?
Citrobacter koseri	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Citrobacter	koseri		NCTC 10768	Indole	indole	798	?				Yes		no mutant	PubMed 4496972												?						?
Clostridioides difficile	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridioides	difficile		CD630	AI-2	AI-2	446576	"Yes"				Yes		no mutant	PubMed 15673504												LuxS		PubMed 15673504	CAJ70505.1	41	QEH48503.1	No		PubMed 15673504						increased transcription of toxin A and B genes	PubMed 16098481	increased biofilm formation	PubMed 23892245
Clostridioides difficile	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridioides	difficile		B1/ NAP1/027 R20291	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 31289293												LuxS		PubMed 31289293	CEK00316.1	41	QEH48503.1	No	proposed	PubMed 31289293						increased biofilm formation	PubMed 31289293	was inhibited in its growth by Bacteroides fragilis in a mixed biofilm, effect was alleviated by LuxS mutant	PubMed 31289293	mediated prophage induction	PubMed 31289293
Clostridioides difficile	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridioides	difficile		R20291	Indole	indole	798	No				No			PubMed 30944877																		No								induced indole production in Escherichia coli strains H10407 and 25922 by induction of expression of tnaA gene	PubMed 30944877
Clostridioides difficile	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridioides	difficile		630	Indole	indole	798	No				No			PubMed 30944877																		No								induced indole production in Escherichia coli strains H10407 and 25922 by induction of expression of tnaA gene	PubMed 30944877
Clostridium novyi	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	novyi		soil isolate	Indole	indole	798	?				Yes?			PubMed 14240950												?						?
Clostridium perfringens	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	perfringens		strain 13	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 11967077												LuxS		PubMed 11967077	BAB79884.1	49	QEH48503.1	No		PubMed 11967077						increased toxin production	PubMed 11967077
Clostridium perfringens	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	perfringens		ATCC 3624	autoinducing peptide	?		Yes?			PubMed 32554714	Yes?			PubMed 25777675												AgrB; AgrD		PubMed 32554714	AFM44967.1	29	AF288215.1	VirR; VirS	proposed	PubMed 25777675	AAA58949.1; AAA58950.1		not comparable	membrane	PubMed 25777675	regulated production of alpha toxin and perfringolysin O toxin	PubMed 25777675
Clostridium perfringens	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	perfringens		strain 13	autoinducing peptide	TSACLWFT, thiolactone linkage between C4 and T8	none	Yes			PubMed 19363118	Yes		Experimental	PubMed 19363118												AgrB; AgrD		PubMed 19363118	BAB81267.1	29	AF288215.1	VirR; VirS	double agrBD-virR/virS knockout mutant showed no activation of transcription of toxin genes	PubMed 19363118	BAA03592.1; BAB81206.1		not comparable	membrane	PubMed 25777675	regulated production of alpha toxin and perfringolysin O toxin	PubMed 19363118	required for gliding motility to invade host tissue at beginning of myonecrosis	PubMed 33130105
Clostridium perfringens	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	perfringens		CN3685	autoinducing peptide	CLWFT, thiolactone linkage between C1 and T5	none	Yes?			PubMed 25777675	Yes		Experimental	PubMed 25777675												AgrB; AgrD		PubMed 25777675	AER57913.1	29	AF288215.1	VirR; VirS	proposed	PubMed 25777675	AAA58949.1; AAA58950.1		not comparable	membrane	PubMed 25777675
Clostridium saccharobutylicum	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	saccharobutylicum		DSM 13864	AI-2	AI-2	446576	Yes		Experimental	PubMed 30696769	Yes		no mutant	PubMed 30696769												LuxS		PubMed 30696769	AGX44040.1	41	QEH48503.1	LsrB	confirmed by crystal structure	PubMed 30696769	AGX43123.1	21	AYO33928.1	extracellular	PubMed 30696769
Clostridium tetani	Bacteria	Firmicutes	Clostridia	Clostridiales	Peptostreptococcaceae	Clostridium	tetani		NCIB 10628	Indole	indole	798	?				Yes		no mutant	PubMed 1275638												?						?
Corynebacterium ammoniagenes	Bacteria	Actinobacteria	Actinobacteria	Corynebacteriales	Corynebacteriaceae	Corynebacterium	ammoniagenes		20305	AI-2	AI-2	446576	?				Yes		no mutant	PubMed notavailable,Jespersenetal.2010												LuxS		PubMed notavailable,Jespersenetal.2010	EFG81512.1	37	QEH48503.1	?
Corynebacterium ammoniagenes	Bacteria	Actinobacteria	Actinobacteria	Corynebacteriales	Corynebacteriaceae	Corynebacterium	ammoniagenes		20306	AI-2	AI-2	446576	?				Yes		no mutant	PubMed notavailable,Jespersenetal.2010												LuxS		PubMed notavailable,Jespersenetal.2010	EFG81512.1	37	QEH48503.1	?
Eikenella corrodens	Bacteria	Proteobacteria	Betaproteobacteria	Neisseriales	Neisseriaceae	Eikenella	corrodens		1073	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 17027872												LuxS		PubMed 17027872	AB243068.1	77	QEH48503.1	?								decreased biofilm formation	PubMed 17027872
Enterobacter asburiae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	asburiae		L1	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		Experimental	PubMed 33150063	Yes		no mutant	PubMed 33150063												EasI		PubMed 33150063	AHW94257.1	25	NP_250123.1	EasR	proposed	PubMed 33150063	AHW94256.1	54	NP_416426.1	cytoplasm	PubMed 11700290
Enterobacter asburiae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	asburiae		L1	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?		Experimental	PubMed 33150063	Yes		no mutant	PubMed 33150063												EasI		PubMed 33150063	AHW94257.1	25	NP_250123.1	EasR	proposed	PubMed 33150063	AHW94256.1	54	NP_416426.1	cytoplasm	PubMed 11700290
Enterobacter cloacae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	cloacae		JLD400	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes		Experimental	PubMed 26075189	No			PubMed 26075189																		SdiA	knockout resulted in non-responsiveness to AHL	PubMed 26075189	AFN80302.1	65	NP_416426.1	cytoplasm	PubMed 11700290
Enterobacter cloacae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	cloacae		JLD400	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes		Experimental	PubMed 26075189	No			PubMed 26075189																		SdiA	knockout resulted in non-responsiveness to AHL	PubMed 26075189	AFN80302.1	65	NP_416426.1	cytoplasm	PubMed 11700290	increased bacterial virulence factor expression	PubMed 26075189
Enterobacter cloacae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	cloacae		ATCC 13047	AI-2	AI-2	446576	Yes?				Yes?			PubMed 16487745												LuxS		PubMed 16487745	KGB12914.1	71	QEH48503.1	RbsB	proposed	PubMed 22778662	AYU96476.1	75	AYO33928.1	periplasm	PubMed 16790775
Enterobacter sp.	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Enterobacter	sp. (cloacae)		T1-1	N-Acyl homoserine lactone	C12-HSL	11565426	?				Yes		Experimental	PubMed 23202161												?						?
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		V583	AI-2	AI-2	446576	"Yes"				Yes		no mutant	PubMed 22856334												LuxS		PubMed 22856334	AO80981.1	43	QEH48503.1	No		PubMed 18803868						regulated metabolism	PubMed 22856334	increased biofilm formation	PubMed 22856334
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		OG1RF	GBAP	QNSPNIFGQWM, lactone linkage between S3 and M11	316933526	Yes		Experimental	PubMed 11454207	Yes		Experimental	PubMed 11344145												FsrB		PubMed 11344145	AEA94215.1	24	AF288215.1	FsrA; FsrC	knockout abgrogated gelatinase biosynthesis, no recovery by GBAP addition	PubMed 11454207	AEA94214.1	28	AF288215.1	membrane	PubMed 11454207	induced gelatinase biosynthesis	PubMed 11454207
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		JH2-2	autoinducing peptide	AIFILAS	none	"Yes"				Yes		no mutant	PubMed 3093276												?						?								induced a mating response of donor cells pf Enterococcus faecalis harboring plasmid pAM373 which leads to mating aggregates	PubMed 3093276
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		FA2-2	autoinducing peptide	AITLIFI	none	Inhibit			PubMed 10736223	Yes		no mutant	PubMed 3139658												?						PrgX	proposed	PubMed 16339309	2AXV_D		not comparable	cytoplasm	PubMed 16339309	inhibited aggregation and high frequency plasmid transfer in Enterococcus faecalis cells carrying the tetracycline resistance plasmid pCF10	PubMed 16339309
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		JH2-2	autoinducing peptide	ALILTLVS	none	Inhibit				Yes		no mutant	PubMed 3104314												?						?								inhibited aggregation of Enterococcus faecalis cells for mating	PubMed 6436978
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		JH2-2	autoinducing peptide	FLVMFLSG	none	"Yes"				Yes		no mutant	PubMed 6436978												Eep		PubMed 10498702	AAD47948.1	100	AF152237.1	?								induced aggregation of Enterococcus faecalis cells for mating	PubMed 6436978
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		OG1S	autoinducing peptide	LFSLVLAG	none	"Yes"				Yes		no mutant	PubMed 6437872												Eep		PubMed 10498702	AAD47948.1	100	AF152237.1	?								induced aggregation of Enterococcus faecalis cells for mating	PubMed 6437872
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		unknown	autoinducing peptide	LFVVTLVG	none	Inhibit			PubMed 2550976	Yes		no mutant	PubMed 2550976												?						?								inhibited aggregation of Enterococcus faecalis cells for mating	PubMed 2550976
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		OG1RF	autoinducing peptide	LVTLVFV	none	Yes			PubMed 10736223	Yes		no mutant	PubMed 2550976												Eep		PubMed 2550976,PubMed PMID:18083822	AZV97405.1	100	AF152237.1	PrgX	confirmed by crystal structure	PubMed 16339309	2AXV_D		not comparable	cytoplasm	PubMed 16339309	induced aggregation and high frequency plasmid transfer in Enterococcus faecalis cells carrying the tetracycline resistance plasmid pCF10	PubMed 2550976
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		FA2-2	autoinducing peptide	SIFTLVA	none	Inhibit			PubMed 7670199	Yes		no mutant	PubMed 7670199												?						?								inhibited high frequency of pAM373 transfer between Enteroccous faecalis cells in liquid medium	PubMed 7670199
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		FA2-2	autoinducing peptide	VAVLVLGA	none	"Yes"				Yes		no mutant	PubMed 7772836												Eep		PubMed 10498702	AAD47948.1	100	AF152237.1	?								induced aggregation of Enterococcus faecalis cells for mating	PubMed 7772836	induced mating response for transfer of pYl1 plasmid between Enterococcus faecalis cells	PubMed 7772836
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		ATCC 29212	AI-2	AI-2	446576	"Yes"				Yes?			PubMed 30304123												LuxS		PubMed 30304123	CAG4699067.1	43	QEH48503.1	?								increased biofilm formation	PubMed 30304123
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		OG1X	autoinducing peptide	ALILTLVS	none	Inhibit			PubMed 9457843	Yes			PubMed 9457843												?						TraA	completely inhibited [3H]cPD1 binding to recombinant TraA	PubMed 9457843	ELA02280.1		not comparable	cytoplasm	PubMed 9457843
Enterococcus faecalis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecalis		OG1X	autoinducing peptide	FLVMFLSG	none	Yes			PubMed 9457843	Yes			PubMed 9457843												Eep		PubMed 9457843,PubMed PMID:10498702	AF152237.1	100	AF152237.1	TraA	bound as [3H]cPD1 to recombinant TraA	PubMed 9457843	ELA02280.1		not comparable	cytoplasm	PubMed 9457843
Enterococcus faecium	Bacteria	Firmicutes	Bacilli	Lactobacillales	Enterococcaceae	Enterococcus	faecium		QQ12		C6-HSL	10058590									YES	PubMed 31955395	AiiA	not known	N-acyl-homoserine lactonase	PubMed 31955395	Predicted			?
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		MG 1655	N-Acyl homoserine lactone	C6-HSL	10058590	Yes		Experimental	PubMed 16487323	No			PubMed 16487323,PubMed PMID:11544237			PvdQ	NP_251075.1														SdiA	knockout abolished response to AHL	PubMed 16487323	NP_416426.1	100	NP_416426.1	cytoplasm	PubMed 11700290	increased acid tolerance	PubMed 16487323
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		MG 1655	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes		Experimental	PubMed 16487323	No			PubMed 16487323,PubMed PMID:11544237			HacB	WP_003160937.1														SdiA	knockout abolished response to AHL	PubMed 16487323	NP_416426.1	100	NP_416426.1	cytoplasm	PubMed 11700290
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		MG 1655	AI-2	AI-2	446576	Yes?		proposed	PubMed 22778662	Yes		no mutant	PubMed 11489131												LuxS		PubMed 11489131	NP_417172.1	69	QEH48503.1	LsrB	proposed	PubMed 22778662	NP_416033.1	24	AYO33928.1	periplasm	PubMed 21097621
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		MG 1655	AI-2	AI-2	446576	Yes?			PubMed 16352847	?															?						LsrB	proposed	PubMed 16352847	NP_416033.1	24	AYO33928.1	periplasm	PubMed 21097621	increased biofilm formation	PubMed 16352847	increased motility	PubMed 16352847
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		VS94	AI-2	AI-2	446576	Yes?			PubMed 18256823	?															?						LsrB	proposed	PubMed 18256823	WP_063123584.1	25	AYO33928.1	periplasm	PubMed 21097621	increased swimming motility	PubMed 18256823	caused chemotactic behavior	PubMed 18256823	altered the expression of 23 locus of enterocyte effacement (LEE) genes directly involved in the production of virulence determinants	PubMed 18256823
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		RP437	AI-2	AI-2	446576	Yes?			PubMed notavailable,Englertetal.2009	?															?						LsrB	proposed	PubMed notavailable,Englertetal.2009	WP_063123584.1	25	AYO33928.1	periplasm	PubMed 21097621	caused chemotactic behavior	PubMed notavailable,Englertetal.2009
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		ATCC 25404	AI-2	AI-2	446576	"Yes"			PubMed 16352847	?															?						?								increased biofilm formation	PubMed 16352847	increased motility	PubMed 16352847
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		E2348y69	AI-2	AI-2	446576	"Yes"			PubMed 10611361	Yes		Experimental	PubMed 10611361												?						?								regulation of the virulent LEE operon	PubMed 10611361
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		ATCC 25404	Indole	indole	798	Yes		Experimental	PubMed 17511876	Yes		Experimental	PubMed 17511876												Tryptophanase TnaA		PubMed 17511876	AMH37037.1	100	AMH37037.1	SdiA	SdiA knockout failed to respond to indole, no change in acid resistance or biofilm	PubMed 17511876	THS65147.1	98	NP_416426.1	cytoplasm	PubMed 11700290	regulated acid resistance	PubMed 17511876	inhibited biofilm formation	PubMed 17511876
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		E2348/69	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 23372726												Tryptophanase TnaA		PubMed 23372726	SNU19340.1	100	AMH37037.1	?								regulated virulence factors and shiga toxin production	PubMed 23372726
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		BW25113	Indole	indole	798	"Yes"				Yes?			PubMed 22387460												Tryptophanase TnaA	proposed	PubMed 22387460	AIN34033.1	100	AMH37037.1	?								inhibited cell division	PubMed 22387460	stabilized multicopy plasmid transmission to daughter cells	PubMed 17163976	reduced biofilm formation	PubMed 16597943
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		MG 1655	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 20811456												Tryptophanase TnaA		PubMed 20811456	AMH37037.1	100	AMH37037.1	?								modulated antibiotic tolerance	PubMed 20811456
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		EMG 2	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 22426114												Tryptophanase TnaA		PubMed 22426114	P0A853.1	100	AMH37037.1	?								induced persister formation	PubMed 22426114
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		Sakai	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 19202102												Tryptophanase TnaA		PubMed 19202102	NP_312672.2	100	AMH37037.1	?								increased formation of A/E lesions in HeLa cells	PubMed 19202102
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		CDC EDL 933	Indole	indole	798	Yes?				Yes?			PubMed 17591798												?						SdiA	proposed	PubMed 17591798	AYV41739.1	99	NP_416426.1	cytoplasm	PubMed 11700290	attenuated infection of EHEC strain	PubMed 17591798
Escherichia coli	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	coli		E2348/69	CAI-1	(S)-3-hydroxytridecan-4-one	24892809	"Yes"			PubMed 30858454	No			PubMed 30858454																		?								upregulated T3SS-related virulence in co-culture with Vibrio cholerae	PubMed 30858454
Escherichia fergusonii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Escherichia	fergusonii		ATCC 35469	Indole	indole	798	?				Yes		no mutant	PubMed 3968204												?						?
Eubacterium rectale	Bacteria	Firmicutes	Clostridia	Clostridiales	Eubacterialeceae	Eubacterium	rectale		A1-86	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 18661296												LuxS		PubMed 18661296	CBK91518.1	27	QEH48503.1	?
Eubacterium ruminantium	Bacteria	Firmicutes	Clostridia	Clostridiales	Eubacterialeceae	Eubacterium	ruminaticum		GA195T	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 12594022												No		PubMed 12594022				?
Fusobacterium nucleatum	Bacteria	Fusobacteria	Fusobacteriia	Fusobacteriales	Fusobacteriaceae	Fusobacterium	nucleatum		ATCC 25586	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 22633049												LuxS		PubMed 22633049	EGQ79049.1	33	QEH48503.1	?								enhanced biofilm growth of Streptococcus gordonii	PubMed 24112724	reduced biofilm growth of Streptococcus oralis	PubMed 24112724
Haemophilus ducreyi	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	ducreyi		35000HP	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 19552526												LuxS		PubMed 19552526	AAP95340.1	72	QEH48503.1	No		PubMed 19552526						increased virulence due to increased pustule formation	PubMed 19552526
Haemophilus influenzae	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	influenzae		NTHI 86-028NP	AI-2	AI-2	446576	Yes		Experimental	PubMed 21923771	Yes		Experimental	PubMed 19564381												LuxS		PubMed 19552526	AAX87545.1	82	QEH48503.1	RbsB	impaired uptake of AI-2 by rbsB mutant, RrsB transcripts correlated with AI-2 concentration	PubMed 21923771	AYO33928.1	100	AYO33928.1	periplasm	PubMed 16790775	important for biofilm formation and persistence	PubMed 21923771	promoted Moraxella catarrhalis persistence within polymicrobial biofilms via interspecies quorum signaling	PubMed 20802829
Haemophilus influenzae	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	influenzae		NCTC 8466	Indole	indole	798	?				Yes		no mutant	PubMed 772168												?						?
Haemophilus influenzae	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	influenzae		NCTC 7279	Indole	indole	798	?				Yes		no mutant	PubMed 772168												?						?
Haemophilus influenzae	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	influenzae		NCTC 8473	Indole	indole	798	?				Yes		no mutant	PubMed 772168												?						?
Haemophilus influenzae	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	influenzae		NCTC 8469	Indole	indole	798	?				Yes		no mutant	PubMed 772168												?						?
Haemophilus somnus	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Haemophilus	somnus		isolate	Indole	indole	798	?				Yes		no mutant	PubMed 922555												?						?
Helicobacter pylori	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Helicobacteraceae	Helicobacter	pylori		Alston	AI-2	AI-2	446576	?				Yes		Experimental	PubMed 10850976												LuxS		PubMed 10850976	ABG76066.1	41	QEH48503.1	No		PubMed 21602215
Helicobacter pylori	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Helicobacteraceae	Helicobacter	pylori		G27	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 21602215												LuxS		PubMed 21602215	ACI26866.1	41	QEH48503.1	AibA; AibB	recapitulated the biofilm structures of the luxS deficient Helicobacter pylori strain	PubMed 26152582	no entry			periplasm	PubMed 26152582	AI-2 acted as a chemorepellent	PubMed 21602215	influenced the proportions and spatial organization of cells within Helicobacter pylori biofilms	PubMed 26152582
Helicobacter pylori	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Helicobacteraceae	Helicobacter	pylori		26695	AI-2	AI-2	446576	No				Yes		Experimental	PubMed 33400843												LuxS		PubMed 33400843	AFV41325.1	40	QEH48503.1	?								reduced expression of adhesins and bacterial adhesion to gastric epithelial cells	PubMed 33400843	reduced the activation of NF-?B and expression of IL-8 in Helicobacter pylori-infected gastric epithelial cells	PubMed 33400843	upregulated the expression of CagM, CagE, and CagX (T4SS elements)	PubMed 33400843
Klebsiella oxytoca	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	oxytoca		clinical isolate	Indole	indole	798	?				Yes		no mutant	PubMed 9276417												?						?
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		T2-1	N-Acyl homoserine lactone	C8-HSL	6914579	?				Yes		Experimental	PubMed 22737019												?						?
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		T2-1	N-Acyl homoserine lactone	C12-HSL	11565426	?				Yes		Experimental	PubMed 22737019												?						?
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		LM21	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 15805533												LuxS		PubMed 15805533	CDO12866.1	69	QEH48503.1	RbsB	proposed	PubMed 22778662	CDO16771.1	75	AYO33928.1	periplasm	PubMed 16790775	involved in early steps of biofilm formation	PubMed 15805533
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		CSG20	N-Acyl homoserine lactone	C6-HSL	10058590	?				Yes		no mutant	PubMed 24284772												?						?
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		KP563	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 32223838												LuxS		PubMed 32223838	CDO12866.1	69	QEH48503.1	?								involved in surface coverage and macrocolony formation during biofilm formation	PubMed 32223838
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		clinical isolate	Indole	indole	798	"Yes"				?															?						?								increased biofilm formation	PubMed 31762509	modulated antibiotic tolerance of Klebsiella pneumoniae	PubMed 31762509
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		CICC 10018	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 27924940												LuxS		PubMed 27924940	CDO12866.1	69	QEH48503.1	?								increased production of acetoin, ethanol and acetic acid	PubMed 27924940	decreased production of 2,3-butanediol	PubMed 27924940
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		KCTC2241		C6-HSL	10058590									YES	PubMed 12777494	AhlK	AAO47340.1	N-acyl-homoserine lactonase	PubMed 12777494	Experimental	100	AAO47340.1	cellular	PubMed 12777494
Klebsiella pneumoniae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Klebsiella	pneumoniae		KCTC2241		3-oxo-C6-HSL	688505									YES	PubMed 12777494	AhlK	AAO47340.1	N-acyl-homoserine lactonase	PubMed 12777494	Experimental	100	AAO47340.1	cellular	PubMed 12777494
Lactobacillus acidophilus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Lactobacillaceae	Lactobacillus	acidophilus		NCFM	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 19302300												LuxS		PubMed 19302300	YP_193957.1	40	QEH48503.1	?								increased adherence to intestinal epithelial cells	PubMed 19302300	transcription of luxS was upregulated in co-culture with Listeria monocytogenes EGD-e	PubMed 21784546
Lactobacillus johnsonii	Bacteria	Firmicutes	Bacilli	Lactobacillales	Lactobacillaceae	Lactobacillus	johnsonii		NCC533	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 19748697												LuxS		PubMed 19748697	AAS09590.1	42	QEH48503.1	?
Lactobacillus plantarum	Bacteria	Firmicutes	Bacilli	Lactobacillales	Lactobacillaceae	Lactobacillus	plantarum		WCFS1	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	"Yes"		Experimental	PubMed 31024494	?															?						?								changed global metabolism with an emphasis on fatty acid synthesis	PubMed 31024494	upregulation of AI-2 synthesizing enzyme LuxS	PubMed 31024494	upregulation of Plantaricin genes	PubMed 31024494	upregulation of genes consistent with both class I and III stress response traditionally caused by general environmental stress	PubMed 31024494
Lactobacillus plantarum	Bacteria	Firmicutes	Bacilli	Lactobacillales	Lactobacillaceae	Lactobacillus	plantarum		ATCC 10241	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 25347359												LuxS		PubMed 25347359	CCC78237.1	40	QEH48503.1	?
Lactobacillus salivarius	Bacteria	Firmicutes	Bacilli	Lactobacillales	Lactobacillaceae	Lactobacillus	salivarius		UCC118	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 19748697												LuxS		PubMed 19748697	ABD99981.1	41	QEH48503.1	?
Leptotrichia buccalis	Bacteria	Fusobacteria	Fusobacteria	Fusobacterales	Leptotrichiaceae	Leptotrichia	buccalis		C-1013-b	AI-2	AI-2	446576	?				Yes?		proposed	PubMed 26277986												LuxS		PubMed 26277986	ACV39637.1	33	QEH48503.1	?
Microbacterium testaceum	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Microbacteriaceae	Microbacterium	testaceum		StLB057		C6-HSL	10058590									YES	PubMed 20173075	AiiM	WP_013585900.1	N-acyl-homoserine lactonase	PubMed 20173075	Experimental	29	AAO47340.1	?
Microbacterium testaceum	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Microbacteriaceae	Microbacterium	testaceum		StLB057		C8-HSL	6914579									YES	PubMed 20173075	AiiM	WP_013585900.1	N-acyl-homoserine lactonase	PubMed 20173075	Experimental	29	AAO47340.1	?
Microbacterium testaceum	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Microbacteriaceae	Microbacterium	testaceum		StLB057		C10-HSL	10131281									YES	PubMed 20173075	AiiM	WP_013585900.1	N-acyl-homoserine lactonase	PubMed 20173075	Experimental	29	AAO47340.1	?
Microbacterium testaceum	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Microbacteriaceae	Microbacterium	testaceum		StLB057		C12-HSL	45266530									YES	PubMed 20173075	AiiM	WP_013585900.1	N-acyl-homoserine lactonase	PubMed 20173075	Experimental	29	AAO47340.1	?
Moraxella catarrhalis	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Moraxellaceae	Moraxella	catarrhalis		7169	AI-2	AI-2	446576	"Yes"				No			PubMed 20802829																		?								increased biofilm formation	PubMed 20802829	increased antibiotic resistance	PubMed 20802829
Morganella morganii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Morganellaceae	Morganella	morganii		ATCC 25830	Indole	indole	798	?				Yes		no mutant	PubMed 11023955												?						?
Mycobacterium abscessus	Bacteria	Actinobacteria	Actinomycetales	Corynebacterineae	Mycobacteriaceae	Mycobacterium	abscessus		DSM 44196		PQS	2763159									YES	PubMed 28303132	AqdC	WP_100492834.1	PQS dioxygenase	PubMed 28303132	Experimental		not comparable	cellular	PubMed 28303132
Mycobacterium tubercolosis	Bacteria	Actinobacteria	Actinomycetales	Corynebacterineae	Mycobacteriaceae	Mycobacterium	tubercolosis		not known	AI-2	AI-2	446576	?				Yes?		proposed	PubMed 9990077												LuxS		PubMed 9990077	SGE33630.1	73	QEH48503.1	?
Mycobacterium tubercolosis	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Mycobacteriaceae	Mycobacterium	tubercolosis		not known		C4-HSL	10130163									YES	PubMed 17105187	PPH	ACF57854.1	phosphotriesterase-like lactonase	PubMed 17105187	Experimental		not comparable	?
Mycobacterium tubercolosis	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Mycobacteriaceae	Mycobacterium	tubercolosis		not known		C10-HSL	10131281									YES	PubMed 17105187	PPH	ACF57854.1	phosphotriesterase-like lactonase	PubMed 17105187	Experimental		not comparable	?
Mycobacterium tubercolosis	Bacteria	Actinobacteria	Actinobacteria	Actinomycetales	Mycobacteriaceae	Mycobacterium	tubercolosis		not known		3-oxo-C8-HSL	127293									YES	PubMed 17105187	PPH	ACF57854.1	phosphotriesterase-like lactonase	PubMed 17105187	Experimental		not comparable	?
Pantoea agglomerans (Enterobacter aggolmerans)	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Pantoea	agglomerans		DAPP-PG 734	N-Acyl homoserine lactone	C4-HSL	10130163	"Yes"		Experimental	PubMed 21677694	Yes		Experimental	PubMed 21677694												PagI		PubMed 21677694	EF494651.1	41	X76082.1	PagR	knockout didn't alter AHL amount produced, no signal transduction via PagR	PubMed 21677694	ACN54748.1	51	NP_416426.1	cytoplasm	PubMed 11700290	increased EPS production	PubMed 21677694
Pantoea agglomerans (Enterobacter aggolmerans)	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Pantoea	agglomerans		DAPP-PG 734	N-Acyl homoserine lactone	C6-HSL	10058590	"Yes"		Experimental	PubMed 21677694	Yes		Experimental	PubMed 21677694												PagI		PubMed 21677694	EF494651.1	41	X76082.1	PagR	knockout didn't alter AHL amount produced, no signal transduction via PagR	PubMed 21677694	ACN54748.1	51	NP_416426.1	cytoplasm	PubMed 11700290	increased EPS production	PubMed 21677694
Pantoea agglomerans (Enterobacter aggolmerans)	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Pantoea	agglomerans		Pag824-1	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		Experimental	PubMed 19522567	Yes	major	Experimental	PubMed 18616406												PagI		PubMed 19522567	EF494651.1	41	X76082.1	PagR	knockout results in reduced gall size of gypsophila	PubMed 19522567	EF494651.1	48	NP_416426.1	cytoplasm	PubMed 11700290	reduction in gall size of gypsophila	PubMed 19522567	decreased transcription of T3SS effectors	PubMed 19522567
Pantoea agglomerans (Enterobacter aggolmerans)	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Pantoea	agglomerans		Pag824-1	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?				Yes	minor	Experimental	PubMed 18616406												PagI		PubMed 19522567	EF494651.1	41	X76082.1	PagR	knockout results in reduced gall size of gypsophila	PubMed 19522567	EF494651.1	48	NP_416426.1	cytoplasm	PubMed 11700290
Pasteurella multocida	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Pasteurella	multocida		USDA	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11786252												LuxS	proposed	PubMed 11786252	AFI45330.1	84	QEH48503.1	LuxP	proposed	PubMed 11786252	no entry
Pasturella multocida	Bacteria	Proteobacteria	Gammaproteobacteria	Pasteurellales	Pasteurellaceae	Pasturella	multocida		isolate	Indole	indole	798	?				Yes		no mutant	PubMed 7040470												?						?
Porphyromonas asaccharolytica	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	asaccharolytica		ATCC 25260	Indole	indole	798	?				Yes		no mutant	PubMed 1774320												?						?
Porphyromonas endodontalis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	ndodontalis		ATCC 35406	Indole	indole	798	?				Yes		no mutant	PubMed 1774320												?						?
Porphyromonas gingivalis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	gingivalis		W50	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 11882711												LuxS		PubMed 11882711	EIW93949.1	30	QEH48503.1	LuxP	proposed	PubMed 11705942	no entry			periplasm	PubMed 21097621	induced biofilm growth and coaggregation with Fusobacterium nucleatum	PubMed 22633049	modulated the expression of the luxS-regulated genes uvrB and hasF	PubMed 11705942
Porphyromonas gingivalis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	gingivalis		ATCC 33277	Indole	indole	798	?				Yes		no mutant	PubMed 1774320												?						?
Porphyromonas gingivalis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	gingivalis		ATCC 33277	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	?				Yes		no mutant	PubMed 32555242												?						?
Porphyromonas gingivalis	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Porphyromonas	gingivalis		ATCC 33277	AI-2	AI-2	446576	"Yes"				Yes		no mutant	PubMed 25434960												LuxS		PubMed 25434960	not consistent			?								induced an inflammatory response in human oral cells in vitro	PubMed 25434960
Prevotella intermedia	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		ATCC 25611	Indole	indole	798	?				Yes		no mutant	PubMed 1774320												?						?
Prevotella intermedia (Bacteroides intermedius)	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		5A369	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11292769												LuxS		PubMed 11292769	SUB96394.1	29	QEH48503.1	?
Prevotella intermedia (Bacteroides intermedius)	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		5A327	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11292769												LuxS		PubMed 11292769	SUB96394.1	29	QEH48503.1	?
Prevotella intermedia (Bacteroides intermedius)	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		5A335	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11292769												LuxS		PubMed 11292769	SUB96394.1	29	QEH48503.1	?
Prevotella intermedia (Bacteroides intermedius)	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		5A338	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11292769												LuxS		PubMed 11292769	SUB96394.1	29	QEH48503.1	?
Prevotella intermedia (Bacteroides intermedius)	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Prevotellaceae	Prevotella	intermedia		5A354	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11292769												LuxS		PubMed 11292769	SUB96394.1	29	QEH48503.1	?
Propionibacterium acnes	Bacteria	Actinobacteria	Actinomycetales	Propionibacteriaceae	Propionibacterium	Propionibacterium	acnes		LMG 16711	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 17399956												LuxS		PubMed 17399956	EFS36811.1	40	QEH48503.1	?
Propionibacterium acnes	Bacteria	Actinobacteria	Actinomycetales	Propionibacteriaceae	Propionibacterium	Propionibacterium	acnes		not known	Indole	indole	798	?				Yes		no mutant	PubMed 24982315												?						?
Proteus mirabilis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Proteus	mirabilis		O18	N-Acyl homoserine lactone	C4-HSL	10130163	"Yes"		Experimental	PubMed 22198843	No			PubMed 22198843																		?								increased biofilm thickness	PubMed 22198843
Proteus mirabilis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Proteus	mirabilis		O18	N-Acyl homoserine lactone	C6-HSL	10058590	No		Experimental	PubMed 22198843	Yes		no mutant	PubMed 22198843												?						?
Proteus mirabilis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Proteus	mirabilis		O18	N-Acyl homoserine lactone	C10-HSL	10131281	"Yes"		Experimental	PubMed 22198843	No			PubMed 22198843																		?								increased biofilm thickness	PubMed 22198843
Proteus mirabilis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Proteus	mirabilis		BB2000	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 11882712												LuxS		PubMed 11882712	AGS59028.1	71	QEH48503.1	RsbA		PubMed 11882712	AGS58768.1		not comparable	inner membrane	PubMed 15916958
Proteus vulgaris	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Proteus	vulgaris		ATCC 13315	Indole	indole	798	?				Yes		no mutant	PubMed 5781572												Tryptophanase		PubMed 5781572	CRL61014.1	53	AMH37037.1	?
Providencia rettgeri	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Morganellaceae	Providencia	rettgeri		ATCC 29944	Indole	indole	798	?				Yes		no mutant	PubMed 11023955												?						?
Providencia stuartii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Morganellaceae	Providencia	stuartii		ATCC 29914	Indole	indole	798	?				Yes		no mutant	PubMed 11023955												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		proposed	PubMed 30114353	Yes	1	Experimental	PubMed 7568146,PubMed PMID:9593307,PubMed PMID:19525275			AhlK	AAO47340.1								VsmI		PubMed 9593307,PubMed PMID:7568146	AAA89074.1	30	NP_250123.1	VsmR	vsmR/vsmI'::lux transcriptional fusion in E. coli responded to C4-HSL	PubMed 7568146	AAA89073.1	41	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?	1	proposed	PubMed 7568146	Yes	0.067	Experimental	PubMed 7568146,PubMed PMID:9593307,PubMed PMID:19525275			AhlK	AAO47340.1								VsmI		PubMed 9593307,PubMed PMID:7568146	AAA89074.1	30	NP_250123.1	VsmR	vsmR/vsmI'::lux transcriptional fusion in E. coli responded to C4-HSL	PubMed 7568146	AAA89073.1	41	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?	0.5	proposed	PubMed 7568146	No			PubMed 7568146			unknown															VsmR	vsmR/vsmI'::lux transcriptional fusion in E. coli responded to C4-HSL	PubMed 7568146	AAA89073.1	41	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Yes?		proposed	PubMed 8278364	Yes		Experimental	PubMed 8278364,PubMed PMID:19525275			unknown									LasI		PubMed 8278364,PubMed PMID:19525275	NP_250123.1	100	NP_250123.1	LasR	lasB-lacZ reporter of lasB promoter activity and lasR under control of the lac promoter in E. coli responded to AHL	PubMed 8278364	AAA25874.1	30	NP_416426.1	cytoplasm	PubMed 11700290	induced apoptosis of macrophages and neutrophiles	PubMed 14500500	inhibited Staphylococcus epidermidis biofilm, initial attachment, and EPS production	PubMed 28804019	induced fragmentation of mitochondria , disruption of cristae and inner membrane ultrastructure in fibroblasts and intestinal epithelial cells	PubMed 32523583	altered major characteristics of respiration and energetics, and decreased mitochondrial membrane potential in fibroblasts and intestinal epithelial cells	PubMed 32523583
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	?				Yes		Experimental	PubMed 19525275			AiiM	WP_013585900.1								LasI		PubMed 19525275	NP_250123.1	100	NP_250123.1	?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Yes?	1	Experimental	PubMed 30559209	Yes		no mutant	PubMed 15686549			AiiM	WP_013585900.1								LasI		PubMed 15686549	EOT21170.1	100	NP_250123.1	LasR	LasR controlled promoter fused to luciferase (plasB-lux) responded to AHL	PubMed 30559209	EOT21168.1	30	NP_416426.1	cytoplasm	PubMed 11700290	3-oxo-C12-HSL induced apoptosis of macrophages and neutrophiles	PubMed 14500500	induced fragmentation of mitochondria , disruption of cristae and inner membrane ultrastructure in fibroblasts and intestinal epithelial cells	PubMed 32523583	altered major characteristics of respiration and energetics, and decreased mitochondrial membrane potential in fibroblasts and intestinal epithelial cells	PubMed 32523583
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	3-oxo-C14-HSL	9883786	Yes?	1	Experimental	PubMed 30559209	No			PubMed 30559209			AiiM	WP_013585900.1														LasR	LasR controlled promoter fused to luciferase (plasB-lux) responded to AHL	PubMed 30559209	EOT21168.1	30	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	Yes?	1	Experimental	PubMed 30559209	No			PubMed 30559209			AiiM	WP_013585900.1														LasR	LasR controlled promoter fused to luciferase (plasB-lux) responded to AHL	PubMed 30559209	EOT21168.1	30	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes?	0.14	Experimental	PubMed 30559209	No			PubMed 30559209			QuiP	AAG04421.1														LasR	LasR controlled promoter fused to luciferase (plasB-lux) responded to AHL	PubMed 30559209	EOT21168.1	30	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes?	0.056	Experimental	PubMed 30559209	No			PubMed 30559209			QuiP	AAG04421.1														LasR	LasR controlled promoter fused to luciferase (plasB-lux) responded to AHL	PubMed 30559209	EOT21168.1	30	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?		proposed	PubMed 15686549	Yes		no mutant	PubMed 15686549			QuiP	AAG04421.1								RhlI		PubMed 15686549	no entry			RhlR	proposed	PubMed 15686549	EOT11185.1	30	NP_416426.1	cytoplasm	PubMed 11700290
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	AI-2	AI-2	446576	Yes		Experimental	PubMed 33097715	No			PubMed 10984043,PubMed PMID:33097715																		PctA; TlpQ	knockout mutants of PctA and TlpC didn't respond to AI-2	PubMed 33097715	NP_252999.1; 6FU4_D		not comparable	membrane	PubMed 33097715	upregulation of virulence factors	PubMed 14651632,PubMed PMID:29089927	regulated biofilm formation	PubMed 26420312
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	2-Alkyl-4-quinolone	C7-AQ	164974	Yes		Experimental	PubMed 23996096	Yes	major	no mutant	PubMed 30336005												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 30336005				PqsR	knockout mutant produces no C7-AQ	PubMed 23996096	NP_249694.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	Pseudomonas quinolone signal	PQS	2763159	Yes		Experimental	PubMed 23996096	Yes	minor	no mutant	PubMed 30336005,PubMed PMID:10500159,PubMed PMID:12426334												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 12426334				PqsR	knockout mutant produces no PQS, no restoration of twitching pr swarming by external PQS	PubMed 23996096	NP_249694.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939	repressed swarming motility	PubMed 23996096	enhanced biofilm formation	PubMed 23996096
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	Pseudomonas quinolone signal	PQS	2763159	Yes		Experimental	PubMed 11724939	Yes		Experimental	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE; PqsH		PubMed 20662781				PqsR/MvfR	knockout abgrogated PQS synthesis	PubMed 11724939	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939	increased production of elastase and phospholipase	PubMed 11724939	increased production of autoinducers 3-oxo-C12-HSL and PQS	PubMed 11724939	increased production of phenazine biosynthesis	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	2-Alkyl-4-quinolone	C7-AQ	164974	Yes		Experimental	PubMed 17083468	Yes		Experimental	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 14739337				PqsR/MvfR	pqsA–lacZ expression was induced by exogenous C7-AQ in pqsA–/pqsH– double mutant (no production of PQS or C7-AQ)	PubMed 17083468	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939	regulated production of AQNOs	PubMed 14739337
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	2-Alkyl-4-quinolone	C6-AQ	594525	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated AQ synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	2-Alkyl-4-quinolone	C8-AQ	594526	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated AQ synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	2-Alkyl-4-quinolone	C9-AQ	none	Yes?			PubMed 14739337	Yes		Experimental	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 14739337				PqsR/MvfR	knockout abgrogated AQ synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	2-Alkyl-4-quinolone	C11-AQ	10063343	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated AQ synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	Pseudomonas quinolone signal	C5-PQS	none	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE; PqsH	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated PQS synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	Pseudomonas quinolone signal	C6-PQS	none	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE; PqsH	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated PQS synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	Pseudomonas quinolone signal	C8-PQS	none	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE; PqsH	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated PQS synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	Pseudomonas quinolone signal	C11-PQS	none	Yes?			PubMed 14739337	Yes		no mutant	PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE; PqsH	proposed	PubMed 14739337				PqsR/MvfR	knockout abgrogated PQS synthesis	PubMed 14739337	EOT20725.1	100	NP_249694.1	membran-associated in cytoplasm	PubMed 11724939
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C5-AQ	594528	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C6-AQ	594525	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C7-AQ	164974	?				Yes	major	no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C8-AQ	594526	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C9-AQ	none	?				Yes	major	no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C11-AQ	10063343	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C7:1-AQ	none	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C9:1-AQ	none	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		P3940	2-Alkyl-4-quinolone	C11:1-AQ	none	?				Yes		no mutant	PubMed 7780603												?						?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		SCV 20265	2-Alkyl-4-quinolone	C7-AQ	164974	?				Yes		no mutant	PubMed 15901684												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 15901684				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		SCV 20265	2-Alkyl-4-quinolone	C9-AQ	none	?				Yes		no mutant	PubMed 15901684												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 15901684				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		SCV 20265	Pseudomonas quinolone signal	PQS	2763159	?				Yes		no mutant	PubMed 15901684												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 15901684				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		SCV 20265	Pseudomonas quinolone signal	C9-PQS	129835684	?				Yes		no mutant	PubMed 15901684												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 15901684				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		SCV 20265	2-Alkyl-4-quinolone	C11-AQ	10063343	?				Yes		no mutant	PubMed 15901684												PqsA; PqsB; PqsC; PqsD; PqsE	proposed	PubMed 15901684				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1	Indole	indole	798	"Yes"				No			PubMed 21261883,PubMed PMID:22101045																		?								attenuated virulence	PubMed 21261883,PubMed PMID:22101045	repressed membrane vesicle production	PubMed 20146747	attenuated production of Pseudomonas quinolone signal	PubMed 20146747
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		YZ1	N-Acyl homoserine lactone	C4-HSL	10130163	?				Yes?			PubMed 29868511												RhlI; LasI	proposed	PubMed 29868511				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		YZ1	N-Acyl homoserine lactone	C8-HSL	6914579	?				Yes?			PubMed 29868511												RhlI; LasI	proposed	PubMed 29868511				?
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		YZ1	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	?				Yes?			PubMed 29868511												RhlI; LasI	proposed	PubMed 29868511				?								induced fragmentation of mitochondria , disruption of cristae and inner membrane ultrastructure in fibroblasts and intestinal epithelial cells	PubMed 32523583	altered major characteristics of respiration and energetics, and decreased mitochondrial membrane potential in fibroblasts and intestinal epithelial cells	PubMed 32523583
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PA14	HHQ	4-hydroxy-2-heptylquinoline	164974	"Yes"			PubMed 14739337	Yes			PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 14739337				?								induced the expression of genes that are also activated by PQS, HHQ is converted by other cells than the producing into PQS	PubMed 14739337
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C7-HSL	443437									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C8-HSL	6914579									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C10-HSL	10131281									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C12-HSL	45266530									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		3-oxo-C12-HSL	3246941									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C14-HSL	58122267									YES	PubMed 16461666	QuiP	AAG04421.1	N-acyl-homoserine lactone acylase	PubMed 16461666	Experimental	99.8	AAG04421.1	periplasm (predicted)	PubMed 16461666
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C7-HSL	443437									YES	PubMed 16495538	PvdQ	NP_251075.1	N-acyl-homoserine lactone acylase	PubMed 16495538	Experimental	99.9	NP_251075.1	cellular	PubMed 16495538
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C8-HSL	6914579									YES	PubMed 16495538	PvdQ	NP_251075.1	N-acyl-homoserine lactone acylase	PubMed 16495538	Experimental	99.9	NP_251075.1	cellular	PubMed 16495538
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		3-oxo-C10-HSL	10221060									YES	PubMed 16495538	PvdQ	NP_251075.1	N-acyl-homoserine lactone acylase	PubMed 16495538	Experimental	99.9	NP_251075.1	cellular	PubMed 16495538
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C12-HSL	45266530									YES	PubMed 16495538	PvdQ	NP_251075.1	N-acyl-homoserine lactone acylase	PubMed 16495538	Experimental	99.9	NP_251075.1	cellular	PubMed 16495538
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		3-oxo-C12-HSL	3246941									YES	PubMed 16495538	PvdQ	NP_251075.1	N-acyl-homoserine lactone acylase	PubMed 16495538	Experimental	99.9	NP_251075.1	cellular	PubMed 16495538
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		C8-HSL	6914579									YES	PubMed 21372094	HacB	WP_003160937.1	N-acyl-homoserine lactone acylase	PubMed 21372094	Experimental	25	NP_251075.1	periplasm (predicted)	PubMed 21372094
Pseudomonas aeruginosa	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	aeruginosa		PAO1		3-oxo-C12-HSL	3246941									YES	PubMed 21372094	HacB	WP_003160937.1	N-acyl-homoserine lactone acylase	PubMed 21372094	Experimental	25	NP_251075.1	periplasm (predicted)	PubMed 21372094
Pseudomonas chlororaphis	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	chlororaphis		30-84	Indole	indole	798	Inhibit			PubMed 25165125	No			PubMed 25165125																		Inhibit								inhibited quorum sensing regulated pigmentation	PubMed 25165125	supressed virulence	PubMed 25165125
Pseudomonas pseudoalcaligenes	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	pseudoalcaligenes		NP103	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	"Yes"		Experimental	PubMed notavailable,Mangwamietal.2016	No			PubMed notavailable,Mangwamietal.2016																		?								increased biofilm thickness	PubMed notavailable,Mangwamietal.2016
Pseudomonas pseudoalcaligenes	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	pseudoalcaligenes		NP103	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	"Yes"		Experimental	PubMed notavailable,Mangwamietal.2016	No			PubMed notavailable,Mangwamietal.2016																		?								increased biofilm thickness	PubMed notavailable,Mangwamietal.2016	increased swarming motility	PubMed notavailable,Mangwamietal.2016	increased autoaggregation	PubMed notavailable,Mangwamietal.2016
Pseudomonas putida	Bacteria	Proteobacteria	Gammaproteobacteria	Pseudomonadales	Pseudomonadaceae	Pseudomonas	putida		DOT-T1E	Indole	indole	798	Yes?				No			PubMed 24373097																		TtgV	proposed	PubMed 24373097	Q93PU6.1		not comparable	cytoplasm	PubMed 24373097	increased antibiotic tolerance	PubMed 24373097
Ruminococcus obeum	Bacteria	Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Ruminococcus	obeum		RUMOBE02774	AI-2	AI-2	446576	Yes?				Yes		no mutant	PubMed 25231861												LuxS		PubMed 25231861	EDM86624.1	31	QEH48503.1	LsrB	proposed	PubMed 25231861	CUP51891.1	27	AYO33928.1	periplasm	PubMed 21097621	decreased colonization factors of Vibrio cholerae	PubMed 25231861
Salmonella enterica ser. Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica serovar Typhimurium		SL1344	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 15790567												LuxS		PubMed 15790567	AAF73475.1	71	QEH48503.1	?								essential for biofilm formation	PubMed 15790567
Salmonella enterica ser. Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica serovar Typhimurium		MET844	AI-2	AI-2	446576	Yes		Experimental	PubMed 15350213	Yes		no mutant	PubMed 15350213												LuxS		PubMed 15350213	AAF73475.1	71	QEH48503.1	LsrB	confirmed by crystal structure	PubMed 15350213	Q8ZKQ1.1	22	AYO33928.1	periplasm	PubMed 15350213
Salmonella enterica ser. Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica serovar Typhimurium		ATCC 14028	AI-2	AI-2	446576	Yes		Experimental	PubMed 11722742	Yes		Experimental	PubMed 11722742												LuxS		PubMed 11722742	AAF73475.1	71	QEH48503.1	LsrB	mutations in lsr operon inhibit AI-2 uptake	PubMed 11722742	Q8ZKQ1.1	22	AYO33928.1	periplasm	PubMed 11722742
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	C6-HSL	10058590	Yes	0.1	Experimental	PubMed 21711544,PubMed PMID:11544237	No			PubMed 11544237			AiiA	not known														SdiA	knockout abolished response to AHL	PubMed 21711544,PubMed PMID:9495757	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290	increased cell invasion	PubMed 11700290
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	C8-HSL	6914579	Yes	0.1	Experimental	PubMed 21711544,PubMed PMID:11544237	No			PubMed 11544237			AqdC	WP_100492834.1														SdiA	knockout abolished response to AHL	PubMed 21711544,PubMed PMID:9495757	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290	increased cell invasion	PubMed 11700290
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	C10-HSL	10131281	Yes	0.01	Experimental	PubMed 11544237	No			PubMed 11544237																		SdiA	knockout abolished response to AHL	PubMed 11544237	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes	0.5	Experimental	PubMed 11544237	No			PubMed 11544237																		SdiA	knockout abolished response to AHL	PubMed 11544237	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes	1	Experimental	PubMed 11544237	No			PubMed 11544237																		SdiA	knockout abolished response to AHL	PubMed 11544237	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290
Salmonella Typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	Yes	0.1	Experimental	PubMed 11544237	No			PubMed 11544237																		SdiA	knockout abolished response to AHL	PubMed 11544237	AAC08299.1	71	NP_416426.1	cytoplasm	PubMed 11700290
Salmonella typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	LT2	Indole	indole	798	"Yes"				No			PubMed 23946425																		?								increased antibiotic tolerance	PubMed 23946425
Salmonella typhimurium	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Salmonella	enterica	subsp. enterica serovar Typhimurium	ATCC 14028s	Indole	indole	798	"Yes"				No			PubMed 22632036																		?								increased antibiotic tolerance	PubMed 22632036	decrased swarming motility	PubMed 22632036
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	C4-HSL	10130163	Yes?	1	Experimental	PubMed 8861211	Yes	1	Experimental	PubMed 8861211												SwrI		PubMed 8861211	AAB18141.1	44	X76082.1	SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211	increased proteolytic activity	PubMed 11160117
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?	0.167	Experimental	PubMed 8861211	Yes	0.1	Experimental	PubMed 8861211												SwrI		PubMed 8861211	AAB18141.1	44	X76082.1	SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?	0.0375	Experimental	PubMed 8861211	No			PubMed 8861211																		SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	3-oxo-C4-HSL	10419888	Yes?	0.025	Experimental	PubMed 8861211	No			PubMed 8861211																		SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes?	0.0167	Experimental	PubMed 8861211	No			PubMed 8861211																		SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211
Serratia liquefaciens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	liquefaciens		MG1	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes?	0.0167	Experimental	PubMed 8861211	No			PubMed 8861211																		SwrR	proposed	PubMed 10074060	AAO38761.1	43	AAN52499.1	cytoplasm	PubMed 11700290	induced swarming motility	PubMed 8861211
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		SS-1	N-Acyl homoserine lactone	C6-HSL	10058590	No		Experimental	PubMed 12354232	Yes	major	Experimental	PubMed 12354232												SpnI		PubMed 12354232	AAN52498.1	37	X76082.1	?
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		SS-1	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes		Experimental	PubMed 12354232	Yes	major	Experimental	PubMed 12354232												SpnI		PubMed 12354232	AAN52498.1	37	X76082.1	SpnR	knockout complemented with synthetic 3-oxo-C6-HSL results in restored phenotypes	PubMed 12354232	AAN52499.1	100	AAN52499.1	cytoplasm	PubMed 11700290	upregulation of prodigiosin, nuclease, biosurfactant, sliding motility	PubMed 12354232
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		SS-1	N-Acyl homoserine lactone	C7-HSL	443437	No		Experimental	PubMed 12354232	Yes	minor	Experimental	PubMed 12354232												SpnI		PubMed 12354232	AAN52498.1	37	X76082.1	?
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		SS-1	N-Acyl homoserine lactone	C8-HSL	6914579	No		Experimental	PubMed 12354232	Yes	minor	Experimental	PubMed 12354232												SpnI		PubMed 12354232	AAN52498.1	37	X76082.1	?
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		SS-1	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	Yes		Experimental	PubMed 12354232	No			PubMed 12354232																		SpnR	knockout complemented with synthetic 3-oxo-C8-HSL results in restored phenotypes	PubMed 12354232	AAN52499.1	100	AAN52499.1	cytoplasm	PubMed 11700290	upregulation of prodigiosin, nuclease, biosurfactant, sliding motility	PubMed 12354232
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		ATCC 274	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 15184576												LuxS		PubMed 15184576	AJ628150.1	71	QEH48503.1	?								induced virulence	PubMed 15184576
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		ATCC 39006	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 15184576												LuxS		PubMed 15184576	Q684Q1.1	71	QEH48503.1	?								induced antibiotic production	PubMed 15184576
Serratia marcescens	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia	marcescens		ATCC 13880	Indole	indole	798	Inhibit			PubMed 25165125	No			PubMed 25165125																		Inhibit								inhibited quorum sensing regulated pigmentation	PubMed 25165125	supressed virulence	PubMed 25165125
Serratia spp.	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Serratia			not known	AI-2	AI-2	446576	Yes?				?															?						RbsB	proposed	PubMed 22778662	WP_049240409.1	71	AYO33928.1	periplasm	PubMed 16790775
Shigella boydii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Shigella	boydii		BS607	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11119484												LuxS	proposed	PubMed 11119484	WP_075332401.1	69	QEH48503.1	?
Shigella dysenteriae	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Shigella	dysenteriae		3818T	AI-2	AI-2	446576	Yes?				Yes		no mutant	PubMed 11119484												LuxS	proposed	PubMed 11119484	VDG92279.1	68	QEH48503.1	LrsB	proposed	PubMed 22778662	no entry
Shigella flexneri	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Shigella	flexneri		2457T	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 11119484												LuxS		PubMed 11119484	Q83JZ4.1	69	QEH48503.1	LrsB	proposed	PubMed 22778662	OCC37652.1	63	AYO33928.1	periplasm	PubMed 15350213
Shigella flexneri	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Shigella	flexneri		not known	N-Acyl homoserine lactone	?		Yes?				No			PubMed 20536120																		SdiA	proposed	PubMed 16307757	QBB80280.1	96	NP_416426.1	cytoplasm	PubMed 11700290
Shigella sonnei	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Shigella	sonnei		BS513	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 11119484												LuxS	proposed	PubMed 11119484	QDI01828.1	69	QEH48503.1	?
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6390	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Inhibit		Experimental	PubMed 16428734	No			PubMed 16428734																		?								inhibited virulence and quorum sensing	PubMed 16428734
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6390B	autoinducing peptide 1	YSTCDFIM, thiolactone linkage between C4 and M8	10306787	Yes		Experimental	PubMed 8618843	Yes		Experimental	PubMed 8618843												AgrB; AgrD		PubMed 8618843	YP_500743.1	89	AF288215.1	AgrA; AgrC	Agr locus knockout was complemented with plasmid encoding agrC, cells expressing AgrC removed AIP activity from supernatant	PubMed 8618843	SQF74337.1	93	AF288215.1	membrane	PubMed 31358609	regulated virulence response like exoprotein production	PubMed 8618843	inhibited RNAIII production of Staphylococcus aureus SA502A, RN7843, RN8462, RN8463	PubMed 9990004,PMID:9197262
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		V8	autoinducing peptide 1	YSTCDFIM, thiolactone linkage between C4 and M8	10306787	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	YP_500743.1	89	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	SQF74337.1	93	AF288215.1	membrane	PubMed 31358609
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		ATCC 27217	autoinducing peptide 2	GVNACSSLF, thiolactone linkage between C5 and F9	none	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	AF001782.1	58	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	AF001782.1	68	AF288215.1	membrane	PubMed 31358609
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6923	autoinducing peptide 2	GVNACSSLF, thiolactone linkage between C5 and F9	none	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	AF001782.1	58	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	AF001782.1	68	AF288215.1	membrane	PubMed 31358609
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		SA502A	autoinducing peptide 2	GVNACSSLF, thiolactone linkage between C5 and F9	none	Yes?			PubMed 9990004	Yes		no mutant	PubMed 9990004												AgrB; AgrD		PubMed 9990004	AAB63264.1	58	AF288215.1	AgrA; AgrC	proposed	PubMed 9990004	AAB63266.1	68	AF288215.1	membrane	PubMed 31358609	inhibited RNAIII production of Staphylococcus aureus RN6390B, RN6596, RN7690, RN7843, RN8462, RN8463	PubMed 9990004,PMID:9197262
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6925	autoinducing peptide 2	GVNACSSLF, thiolactone linkage between C5 and F9	none	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	AF001782.1	58	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	AF001782.1	68	AF288215.1	membrane	PubMed 31358609
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN8462	autoinducing peptide 3	INCDFLL, thiolactone linkage between C3 and L7	none	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	AF001783.1	74	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	AF001783.1	77	AF288215.1	membrane	PubMed 31358609	inhibited RNAIII production of Staphylococcus aureus RN6390B, RN6596, RN7690, SA502A	PubMed 9197262
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN8463	autoinducing peptide 3	INCDFLL, thiolactone linkage between C3 and L7	none	Yes?				Yes		no mutant	PubMed 9197262												AgrB; AgrD		PubMed 9197262	AF001783.1	74	AF288215.1	AgrA; AgrC	proposed	PubMed 9197262	AF001783.1	77	AF288215.1	membrane	PubMed 31358609	inhibited RNAIII production of Staphylococcus aureus RN6390B, RN6596, RN7690, SA502A	PubMed 9990004,PMID:9197262
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN4850	autoinducing peptide 4	YSTCYFIM, thiolactone linkage between C4 and M8	none	Yes		Experimental	PubMed 11053400	Yes		no mutant	PubMed 11053400												AgrB; AgrD		PubMed 11053400	AF288215.1	100	AF288215.1	AgrA; AgrC	AgrAC knockout was complemented by AIP activity from supernatant	PubMed 11053400	AF288215.1	100	AF288215.1	membrane	PubMed 31358609
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6607	autoinducing peptide 2	GVNACSSLF, thiolactone linkage between C5 and F9	none	Yes?				Yes		no mutant	PubMed 11053400,PubMed PMID:12591958												AgrB; AgrD	proposed	PubMed 11053400	AF001782.1	58	AF288215.1	AgrA; AgrC	proposed	PubMed 11053400	AF001782.1	68	AF288215.1	membrane	PubMed 31358609	inhibited ArgC from Staphylococcus aureus RN4850	PubMed 11053400
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN8465	autoinducing peptide 3	INCDFLL, thiolactone linkage between C3 and L7	none	Yes?				Yes		no mutant	PubMed 11053400,PubMed PMID:12591958												AgrB; AgrD	proposed	PubMed 11053400	AF001783.1	74	AF288215.1	AgrA; AgrC	proposed	PubMed 11053400	AF001783.1	68	AF288215.1	membrane	PubMed 31358609	inhibited ArgC from Staphylococcus aureus RN4850	PubMed 11053400
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		ATCC 25923	Indole	indole	798	Inhibit			PubMed 23318836	No			PubMed 23318836																		Inhibit								inhibited hemolytic ability	PubMed 23318836	decreased virulence	PubMed 23318836
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		ATCC BAA-1707	Indole	indole	798	Inhibit			PubMed 23318836	No			PubMed 23318836																		Inhibit								inhibited hemolytic ability	PubMed 23318836	decreased virulence	PubMed 23318836
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		RN6390B	autoinducer RNAIII-activating protein RAP	RAP	none	Yes		Experimental	PubMed 11160124	Yes		no mutant	PubMed 7533297,PubMed PMID:12829282												?						TRAP	synthesis of the virulence regulatory molecule RNAIII is not activated by RAP in the trap mutant strain	PubMed 11160124	AF202641.1		not comparable	membrane-associated	PubMed 12829282	regulated virulence	PubMed 12829282
Staphylococcus aureus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	aureus		USA300	Farnesol	farnesol	445070	Yes?			PubMed 31280653	No			PubMed 31280653																		CrtM	proposed	PubMed 31280653	no entry			cytoplasm	PubMed 25325933	inhibited production of virulence factor staphyloxanthin pigment	PubMed 31280653	increased tolerance to vancomycin	PubMed 28893777
Staphylococcus epidermidis	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	epidermidis		1457	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 18182108												LuxS		PubMed 18182108	VEJ62046.1	43	QEH48503.1	?								regulated virulence factors	PubMed 18182108
Staphylococcus epidermidis	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	epidermidis		Tü3298	autoinducing peptide 1	DSVCASYF, thiolactone linkage between C4 and F8	none	Yes?				Yes		no mutant	PubMed 9537521												AgrB; AgrD	proposed	PubMed 9537521	Z49220.1	49	AF288215.1	AgrA; AgrC	proposed	PubMed 9537521	Z49220.1	54	AF288215.1	membrane	PubMed 31358609	inhibited Staphylococcus aureus virulence factor expression	PubMed 10359085
Staphylococcus epidermidis	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	epidermidis		clinical isolate 5183, Fey collection	autoinducing peptide 3	NAAKYNPCASYL, thiolactone linkage between C8 and L12		Yes		Experimental	PubMed 25070736	Yes		no mutant	PubMed 25070736												AgrB; AgrD	proposed	PubMed 25070736	Z49220.1	49	AF288215.1	AgrA; AgrC	proposed	PubMed 25070736	Z49220.1	54	AF288215.1	membrane	PubMed 31358609	repressed RNAIII production of Staphylococcus epidermidis ATCC12228	PubMed 25070736
Staphylococcus epidermidis	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	epidermidis		clinical isolate 4804, Fey collection	autoinducing peptide 2	NASKYNPCSNYL, thiolactone linkage between C8 and L12		Yes		Experimental	PubMed 25070736	Yes		no mutant	PubMed 25070736												AgrB; AgrD	proposed	PubMed 25070736	Z49220.1	49	AF288215.1	AgrA; AgrC	proposed	PubMed 25070736	Z49220.1	54	AF288215.1	membrane	PubMed 31358609	required to induce Ecp protease activity and production of low-molecular weight proteins	PubMed 25070736	repressed RNAIII production of Staphylococcus epidermidis ATCC12228	PubMed 25070736
Staphylococcus haemolyticus	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	haemolyticus		Id. 1312	autoinducing peptide	SFTPCTTYF, thiolactone linkage between C5 and F9	none	?				Yes		no mutant	PubMed 31011175												?						?
Staphylococcus lugdunensis	Bacteria	Firmicutes	Bacilli	Bacillales	Staphylococcaceae	Staphylococcus	lugdunensis		A1	autoinducing peptide 2	DMCNGYF, thiolactone linkage between C3 and F7	none	?				Yes		no mutant	PubMed 31011175												?						?
Streptococcus anginosus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	anginosus		NCTC 10713	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 16897563												LuxS		PubMed 16897563	DQ067600.1	40	QEH48503.1	?								increased biofilm formation	PubMed 16897563	decreased susceptibility to erythromycin and ampicillin	PubMed 17491000
Streptococcus anginosus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	anginosus		NCTC 10713	Competence stimulating peptide	DSRIRMGFDFSKLFGK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000864.1	0	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000864.1	30	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus constellatus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	constellatus		CCUG 24889	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 16897563												LuxS		PubMed 16897563	VUX02566.1	40	QEH48503.1	?
Streptococcus constellatus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	constellatus		NCTC 11325	Competence stimulating peptide	DSRIRMGFDFSKLFGK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000867.1	42	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000867.1	29	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus cristatus	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	cristatus		NCTC 12479	Competence stimulating peptide	DLRNIFLKIKFKKK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	CAA04366.1	45	U33315.1	ComD; ComE	proposed	PubMed 9352904	EFX52454.1	29	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus gordonii	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	gordonii		DL1 Challis	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 12486064												LuxS		PubMed 12486064	ABV09736.1	39	QEH48503.1	?								essential for biofilm formation with Porphyromonas gingivalis	PubMed 12486064	altered microcolony architecture within Streptococcus gordonii biofilms formed in saliva	PubMed 12897005	influenced biofilm architecture within Streptococcus oralis co-biofilms	PubMed 22493304
Streptococcus gordonii	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	gordonii		ATCC 10558	AI-2	AI-2	446576	"Yes"				Yes?		no mutant	PubMed 24112724												LuxS		PubMed 24112724	KTF21704.1	31	QEH48503.1	?								increased biofilm growth and attachment to Fusobacterium nucleatum biofilms	PubMed 24112724
Streptococcus gordonii	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	gordonii		M5	AI-2	AI-2	446576	"Yes"				Yes?		no mutant	PubMed 24112724												LuxS		PubMed 24112724	AAL87464.1	39	QEH48503.1	?								increased biofilm growth and attachment to Fusobacterium nucleatum biofilms	PubMed 24112724
Streptococcus gordonii	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	gordonii		NCTC 3165	Competence stimulating peptide 1	SQKGVYASQRSFVPSWFRKIFRN	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC1	proposed	PubMed 9352904	AJ000870.1	38	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000870.1	30	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus intermedius	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	intermedius		NCTC 11324	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 18954356												LuxS		PubMed 18954356	ABH04322.1	40	QEH48503.1	?								increased biofilm formation	PubMed 18954356	decreased susceptibility to erythromycin and ampicillin	PubMed 19596873	increased biofilm formation at sub-MICs of antibiotic	PubMed 19596873
Streptococcus intermedius	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	intermedius		NCDO 2227T	Competence stimulating peptide	DSRIRMGFDFSKLFGK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000869.1	0	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000869.1	29	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus milleri	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	milleri		NCTC 10708	Competence stimulating peptide	DRRDPRGIIGIGKKLFG	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000868.1	43	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000868.1	29	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus mitis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mitis		ATCC 49456	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 26903968												LuxS		PubMed 26903968	QBZ12314.1	38	QEH48503.1	?								increased Pseudomonas aeruginosa PAO1 biofilm formation	PubMed 26903968
Streptococcus mitis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mitis		NCTC 12261T	Competence stimulating peptide 2	EIRQTHNIFFNFFKRR	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC2	proposed	PubMed 9352904	AJ000875.1	74	U33315.1	ComD; ComE	proposed	PubMed 9352904	CAA04360.1	30	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904	activated both ComD receptors of Streptococcus pneumoniae	PubMed 32905481
Streptococcus mitis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mitis		B5	Competence stimulating peptide 1	ESRLPKIRFDFIFPRKK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC1	proposed	PubMed 9352904	AJ000871.1	83	U33315.1	ComD; ComE	proposed	PubMed 9352904	CAA04360.1	30	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus mitis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mitis		B6	Competence stimulating peptide	EMRKPDGALFNLFRRR	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000865.1	96	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000865.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus mitis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mitis		Hu8	Competence stimulating peptide	EMRKSNNNFFHFLRRI	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000866.1	93	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000866.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		UA159	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 17981981												LuxS		PubMed 17981981	Q8DVK8.1	41	QEH48503.1	?								regulated stress-related genes	PubMed 17981981	regulated biofilm formation	PubMed 17981981,PubMed PMID:12654815
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		ATCC 700610	short hydrophobic peptide	ETIIIIGGG	none	Yes?				Yes		Experimental	PubMed 23776602												?						Rgg	proposed	PubMed 23776602	BBK79856.1	100	BBK79856.1	cytoplasm	PubMed 23776602
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		ATCC 700610	short hydrophobic peptide	VNCWGKH, with tetrahydro[5,6]benzindole modification	none	Yes			PubMed 33727351	Yes			PubMed 33727351												Ras		PubMed 33727351	WP_195915185.1			PdrA	knockout complemented with synthetic SHP resulted in induction of shp-luciferase reporter assay	PubMed 33727351	WP_002352338.1	99	BBK79856.1	cytoplasm	PubMed 33727351	inhibited growth of other streptococci	PubMed 33727351
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		GS-5	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 15870324												LuxS		PubMed 15870324	Q8DVK8.1	41	QEH48503.1	?								regulated glucosyltransferase genes required for sucrose-dependent biofilm formation	PubMed 15870324
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		UA159	Competence stimulating peptide	SGSLSTFFRLFNRSFTQA	none	Yes			PubMed 26553848	Yes		no mutant	PubMed 22923597,PubMed PMID:26553848												ComC		PubMed 22923597	not consistent			ComD		PubMed 26553848	AAN59527.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 22923597,PubMed PMID:26553848	regulated biofilm formation	PubMed 29990430	necessary for mutacin production	PubMed 22923597
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		UA159	Indole	indole	798	"Yes"			PubMed 32350164	No			PubMed 32350164																		?								enhanced biofilm formation	PubMed 32350164
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		NG8	Competence stimulating peptide	SGSLSTFFRLFNRSFTQALGK (pre-peptide)	none	Yes		Experimental	PubMed 11208787	Yes		Experimental	PubMed 11976299												ComC		PubMed 11976299	not consistent			ComD	knockout resulted in 100-fold lower transformation efficiency	PubMed 11208787	AAN59527.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	regulated biofilm formation	PubMed 11976299	required for genetic competence	PubMed 11208787
Streptococcus mutans	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	mutans		UA159	SigX-inducing peptide	GLDWWSL	none	Yes		Experimental	PubMed 20969646	Yes		Experimental	PubMed 20969646												ComS		PubMed 20969646	no entry			ComR	knockout abolished transformability	PubMed 20969646	not consistent			cytoplasm	PubMed 20969646	required for genetic competence	PubMed 24118108
Streptococcus oralis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	oralis		34	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 16796680												LuxS		PubMed 16796680	DQ207739.1	39	QEH48503.1	?								suppression of biofilm formation	PubMed 16796680
Streptococcus oralis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	oralis		NCTC 11427T	Competence stimulating peptide	DKRLPYFFKHLFSNRTK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000873.1	51	U33315.1	ComD; ComE	proposed	PubMed 9352904	AJ000873.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus oralis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	oralis		ATCC 10557	Competence stimulating peptide	DKRLPYFFKHLFSNRTK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	BAJ52713.1	51	U33315.1	ComD; ComE	proposed	PubMed 9352904	AB501215.1	29	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus oralis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	oralis		DSM 20066	Competence stimulating peptide	DWRISETIRNLIFPRRK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000874.1	54	U33315.1	ComD; ComE	proposed	PubMed 9352904	not consistent					required for genetic competence	PubMed 9352904
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		D39	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 12761100												LuxS		PubMed 12761100	ABJ54495.1	38	QEH48503.1	?								required for full virulence	PubMed 12761100	required for biofilm formation	PubMed 23403556
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		CP1200	Competence stimulating peptide 1	EMRLSKFFRDFILQRKK	none	Yes?			PubMed 8878046	Yes		no mutant	PubMed 8878046,PubMed PMID:7479953												ComC1		PubMed 8878046	U33315.1	100	U33315.1	ComD1; ComE	insertion mutant lost endogenous induction of competence	PubMed 8878046	U33315.1	28	AF288215.1	membrane	PubMed 27199267	required for genetic competence	PubMed 8878046
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		A66	Competence stimulating peptide 2	EMRISRIILDFLFLRKK	none	"Yes"			PubMed 8830714	Yes		no mutant	PubMed 8830714												ComC2		PubMed 8830714	X95385.1	80	U33315.1	?								required for genetic competence	PubMed 8830714
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		NCTC 7465T	Competence stimulating peptide 1	EMRLSKFFRDFILQRKK	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC1	proposed	PubMed 9352904	AAC44895.1	100	U33315.1	ComD; ComE	proposed	PubMed 9352904	AAC44896.1	28	AF288215.1	membrane-associated with extracellular loops	PubMed 27199267	required for genetic competence	PubMed 9352904
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		PN4595-T23	Virulence peptide 1	FGTPWSITNFWKKNFNDRPDFDSDRRRY	none	Yes		Experimental	PubMed 28557053	Yes		Experimental	PubMed 28557053												?						Rgg	knockout decreased vp1 gene expression, activation dependent on SHP (MKKQILTLLKIVAEIIIILPFLTNR)	PubMed 28557053	WP_164226264.1	31	BBK79856.1	cytoplasm	PubMed 21829369	played a role in pneumococcal in vivo survival and pathogenesis in a chinchilla infection model	PubMed 28557053	increased thickness and biomass for biofilms grown on chinchilla middle ear epithelial cells	PubMed 28557053
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		KNR.7/87	Bacteriocin-like peptide	GLWEDLLYNINRYAHIT	none	Yes?			PubMed 10940007	Yes	proposed	no mutant	PubMed 10940007												BlpC		PubMed 10940007	CAC03517.1		not comparable	BplH	proposed	PubMed 10940007	CAC03516.1		not comparable	membrane	PubMed 10940007	regulated bacteriocin production	PubMed 10940007	regulated expression of immunity proteins	PubMed 10940007
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		R6	Bacteriocin-like peptide	GWWEELLHETILSKFKITKALELPIQL	none	Yes		Experimental	PubMed 10940007	Yes	proposed	no mutant	PubMed 10940007												BlpC		PubMed 10940007	ABJ54510.1		not comparable	BplH	knockout resulted in no induction of bpl genes	PubMed 10940007	ABJ53623.1		not comparable	membrane	PubMed 10940007	regulated bacteriocin production	PubMed 10940007	regulated expression of immunity proteins	PubMed 10940007
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		R6	Short hydrophobic peptide	DIIIIVGG	none	Yes		Experimental	PubMed 28932816	Yes	proposed	no mutant	PubMed 28932816												Eep	proposed	PubMed 28932816	AAK99046.1		AF152237.1	Rgg	knockout treated with the synthetic pheromone showed no upregulation of shp gene expression	PubMed 28932816	not consistent			cytoplasm	PubMed 21829369	regulated capsule biosynthesis	PubMed 28932816
Streptococcus pneumoniae	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pneumoniae		MGAS10870	SIP	MWLLLLFL	none	Yes		Experimental	PubMed 28923955	Yes		Experimental	PubMed 28923955												No						RopB	speB expression was abolished	PubMed 28923955	no entry			cytoplasm	PubMed 28923955	regulated production of Streptococcal pyrogenic exotoxin B (SpeB)	PubMed 28923955
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		M6 S165	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	Inhibit		Experimental	PubMed 28303956	?															?						LuxR	knockout didn't affect hemolytic activity, increase in transcript levels of LuxR by AHL	PubMed 28303956	AAT87912.1	25	NP_416426.1	cytoplasm	PubMed 11700290	inhibition of hemolytic activity and growth	PubMed 28303956
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		M6 S165	N-Acyl homoserine lactone	3-oxo-C14-HSL	9883786	Inhibit		Experimental	PubMed 28303956	?															?						LuxR	knockout didn't affect hemolytic activity, increase in transcript levels of LuxR by AHL	PubMed 28303956	AAT87912.1	25	NP_416426.1	cytoplasm	PubMed 11700290	inhibition of hemolytic activity and growth	PubMed 28303956
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		ATCC 700294	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 18973658												LuxS		PubMed 18973658	NP_269689.3	40	QEH48503.1	No		PubMed 12855737						regulation of bacterial survival strategies	PubMed 18973658
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		M19 type	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 18973658												LuxS		PubMed 18973658	ANC27517.1	40	QEH48503.1	No		PubMed 12855737						regulation of virulence factor expression	PubMed 18973658	regulation of bacterial survival strategies	PubMed 18973658
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		HSC5	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 11679074												LuxS		PubMed 11679074	AGQ27982.1	39	QEH48503.1	No		PubMed 12855737						regulation of virulence factor expression	PubMed 11679074
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		SP268 serotype M3	AI-2	AI-2	446576	"Yes"				Yes		Experimental	PubMed 14500483												LuxS		PubMed 14500483	BAU59926.1	40	QEH48503.1	No		PubMed 12855737						regulated expression of virulence factors associated with epithelial cell internalization	PubMed 14500483
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		M49	autoinducing peptide 2	DIIIIVGG	none	Yes			PubMed 21829369	Yes			PubMed 21829369												Eep		PubMed 21829369	ACI61878.1	54	AF152237.1	Rgg2	shp-luciferase reporter assay with knockout mutant of rgg2 didn't give a detectable signal, complementation with rgg2 gene resulted in an induction	PubMed 21829369	WP_002990747.1	27	BBK79856.1	cytoplasm	PubMed 21829369	promoted biofilm biogenesis	PubMed 21829369	induced luciferase reporter assay of Streptococcus mutans ATCC 700610	PubMed 23776602
Streptococcus pyogenes	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	pyogenes		M49	autoinducing peptide 3	DILIIVGG	none	Inhibit			PubMed 21829369	Yes			PubMed 21829369												Eep		PubMed 21829369	ACI61878.1	54	AF152237.1	Rgg3	shp-luciferase reporter assay with knockout mutant of rgg3 resulted in a strong induction, complementation with rgg3 gene resulted in baseline induction	PubMed 21829369	WP_012560528.1	27	BBK79856.1	cytoplasm	PubMed 21829369	promoted biofilm biogenesis	PubMed 21829369
Streptococcus sanguis	Bacteria	Firmicutes	Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	sanguis		NCTC 7863T	Competence stimulating peptide	DLRGVPNPWGWIFGR	none	"Yes"			PubMed 9352904	Yes?			PubMed 9352904												ComC	proposed	PubMed 9352904	AJ000872.1	0	U33315.1	ComD; ComE	proposed	PubMed 9352904	no entry					required for genetic competence	PubMed 9352904
Tannerella forsythia	Bacteria	Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Tannerella	forsythia		ATCC 43037	AI-2	AI-2	446576	"Yes"				?															?						?								induced biofilm growth and coaggregation with Fusobacterium nucleatum via induced expression of bacterial adhesin BspA	PubMed 22633049
Treponema denticola	Bacteria	Spirochaetes	Spirochaetia	Spirochaetales	Spirochaetaceae	Treponema	denticola		ATCC 33521	AI-2	AI-2	446576	"Yes"				No			PubMed 12941391																		?								induced expression of bacterial adhesin Msp	PubMed 22633049
Treponema denticola	Bacteria	Spirochaetes	Spirochaetia	Spirochaetales	Spirochaetaceae	Treponema	denticola		isolate	Indole	indole	798	?				Yes		no mutant	PubMed 5788714												?						?
Veillonella tobetsuensis	Bacteria	Firmicutes	Negativicutes	Selenomonadales	Veillonellaceae	Veillonella	tobetsuensis		ATCC BAA-2400T	AI-2	AI-2	446576	?				Yes		no mutant	PubMed notavailable,Mashimaetal.2017												LuxS		PubMed notavailable,Mashimaetal.2017	no entry			?								inhibited Streptococcus gordonii biofilm formation	PubMed notavailable,Mashimaetal.2017
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	C4-HSL	10130163	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-OH-C4-HSL	10330086	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-OH-C8-HSL	274418323	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	C10-HSL	10131281	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	"Yes"		Experimental	PubMed 28670299	Yes		no mutant	PubMed 28670299												?						?								regulated biofilm thickness	PubMed 28670299
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	C12-HSL	11565426	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-OH-C12-HSL	11507677	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		marine isolate	N-Acyl homoserine lactone	3-oxo-C14-HSL	9883786	?				Yes		no mutant	PubMed 28670299												?						?
Vibrio alginolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	alginolyticus		ATCC 33787	Indole	indole	798	?				Yes		no mutant	PubMed 24086529												?						?
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		NB10	N-Acyl homoserine lactone	C6-HSL	10058590	?				Yes	minor	Experimental	PubMed 11872713,PubMed PMID:11371516												VanM		PubMed 11872713,PubMed PMID:11371516	AAG01003.1	33	AAA89074.1	?
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		ATCC 19264	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 9190823												LuxS		PubMed 9190823	ABE98251.1	73	QEH48503.1	?
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		NB10	AI-2	AI-2	446576	Yes?				?															?						VanP	proposed	PubMed 15186417	AY525158.1	24	AYO33928.1	periplasm	PubMed 21097621	decreased expression of metalloprotease empA	PubMed 15186417
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		NB10	Indole	indole	798	"Yes"				Yes		no mutant	PubMed 25360804												Tryptophanase TnaA		PubMed 25360804	CDQ49648.1	83	AMH37037.1	?								decreased biofilm formation	PubMed 25360804	decreased virulence	PubMed 25360804
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		NB10	N-Acyl homoserine lactone	3-OH-C6-HSL	70185030	?				Yes	major	Experimental	PubMed 11872713,PubMed PMID:11371516												VanM		PubMed 11872713,PubMed PMID:11371516	AAG01003.1	33	AAA89074.1	?		PubMed 11371516
Vibrio anguillarum	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	anguillarum		NB10	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	Yes			PubMed 11371516	Yes	major	Experimental	PubMed 11371516												VanI		PubMed 11371516	AAC45212.1	30	AAA89074.1	VanR	knockout abolished AHL production	PubMed 11371516	AAC45213.1	27	NP_416426.1	cytoplasm	PubMed 11700290
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		TSM301	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 9190823												LuxS		PubMed 9190823	AAF93725.1	73	QEH48503.1	?
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		C6706	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 9190823												LuxS		PubMed 9190823	AAF93725.1	73	QEH48503.1	?
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		569B	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 9190823												LuxS		PubMed 9190823	AAF93725.1	73	QEH48503.1	?
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		El Tor C6706str2	AI-2	AI-2	446576	Yes		Experimental	PubMed 12176318	Yes		Experimental	PubMed 12176318												LuxS		PubMed 12176318	THE31094.1	73	QEH48503.1	LuxP	knockout mutant of LuxP and CqsS didn't respond to AI-2, no luminescence	PubMed 12176318	BAE87105.1	26	AYO33928.1	periplasm	PubMed 21097621	decreased virulence factor expression	PubMed 12176318
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		El Tor C6706str2	CAI-1	(S)-3-hydroxytridecan-4-one	24892809	Yes		Experimental	PubMed 12176318	Yes		Experimental	PubMed 12176318												CqsA		PubMed 12176318	SNC57713.1	99	AWA80161.1	CqsS	CqsS knockout failed to activate bioluminescence assay (artifical in V. cholerae)	PubMed 12176318	TYC37058.1		not comparable	membrane	PubMed 21219472	repressed virulence factor production	PubMed 12176318
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		O1 El Tor strain N16961	CAI-1	(S)-3-hydroxytridecan-4-one	24892809	?				Yes?			PubMed 19631226												CqsA		PubMed 19631226	AWA80161.1	100	AWA80161.1	?
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		SIO	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 17496082												Tryptophanase TnaA		PubMed 19329638,PubMed PMID:17496082	AKB06485.1	86	AMH37037.1	DksA; VpsR	proposed	PubMed 19329638	OFJ19496.1; AAK00610.1		not comparable	cytoplasm	PubMed 24354846,PubMed PMID:19889089	increased biofilm formation	PubMed 19329638	increased auto-aggregation	PubMed 19329638	activated polysaccharide production	PubMed 19329638
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		TP	Indole	indole	798	"Yes"				Yes		Experimental	PubMed 17496082												Tryptophanase TnaA		PubMed 19329638,PubMed PMID:17496082	AKB06485.1	86	AMH37037.1	?								increased biofilm formation	PubMed 19329638
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		O1 El Tor strain N16961	Indole	indole	798	"Yes"				?															?						?								increased biofilm formation	PubMed 19329638
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		C6706	DPO	3,5-dimethylpyrazin-2-ol	13123639	Yes		Experimental	PubMed 28319101	Yes		Experimental	PubMed 28319101												Tdh		PubMed 28319101	QJS94478.1		not comparable	VqmA	DPO was isolated bound to VqmA, FLAG-vqmA fusion was activated by external DPO, crystal structure of DPO-VqmA	PubMed 28319101,PubMed PMID:31964715	6UGL_B		not comparable	cytoplasm	PubMed 28319101	inhibited biofilm formation	PubMed 28319101	detected lack of oxygen	PubMed 32723922	detected presence of bile salts	PubMed 32723922
Vibrio cholerae	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	cholerae		O1 El Tor strain N16961	HHQ	4-hydroxy-2-heptylquinoline	164974	?				No			PubMed 31860435																		?								diminished growth	PubMed 31860435
Vibrio parahaemolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	parahaemolyticus		MTCC 451	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?		Experimental	PubMed 27777468	No			PubMed 27777468																		OpaR	proposed	PubMed 27777468,PubMed PMID:9620967	AAC46404.1	27	NP_416426.1	cytoplasm	PubMed 11700290	increased biofilm formation	PubMed 27777468
Vibrio parahaemolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	parahaemolyticus		LM5312	AI-2	AI-2	446576	Yes?				Yes		no mutant	PubMed 15175293												LuxS		PubMed 15175293	QEL39269.1	76	QEH48503.1	LuxP	proposed	PubMed 15175293	SUQ08602.1	22	AYO33928.1	periplasm	PubMed 21097621
Vibrio parahaemolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	parahaemolyticus		clinical isolate	Indole	indole	798	?				Yes		no mutant	PubMed 22535979												?						?
Vibrio parahaemolyticus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	parahaemolyticus		RIMD 2210633	3-hydroxyundecan-4-one	3-hydroxyundecan-4-one	59549980	"Yes"			PubMed 59549980	Yes		Experimental	PubMed 31686391												CqsA		PubMed 31686391	WP_005481314.1		not comparable	?								regulated colony morphology	PubMed 31686391
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		CECT 5763	N-Acyl homoserine lactone	C4-HSL	10130163	?				Yes		Experimental	PubMed 19453744												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	C4-HSL	10130163	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	C6-HSL	10058590	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	3-oxo-C8-HSL	127293	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	3-oxo-C10-HSL	10221060	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	3-oxo-C12-HSL	3246941	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		not known	N-Acyl homoserine lactone	3-oxo-C14-HSL	9883786	?				Yes		no mutant	PubMed 12885081												?						?
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		MO6-24/O	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 12791145												LuxS		PubMed 12791145	ADV85535.1	74	QEH48503.1	LuxP	proposed	PubMed 22696215	ADV89147.1	24	AYO33928.1	periplasm	PubMed 21097621	increased protease production	PubMed 12791145	decreased hemolysin production	PubMed 12791145
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		ATCC 29307	AI-2	AI-2	446576	Yes?				Yes		no mutant	PubMed 12791145												LuxS		PubMed 12791145	AF305637.1	74	QEH48503.1	LuxP	proposed	PubMed 22696215	OJI52872.1	24	AYO33928.1	periplasm	PubMed 21097621
Vibrio vulnificus	Bacteria	Proteobacteria	Gammaproteobacteria	Vibrionales	Vibrionaceae	Vibrio	vulnificus		YJ016	HHQ	4-hydroxy-2-heptylquinoline	164974	"Yes"			PubMed 14739337	Yes			PubMed 14739337												PqsA; PqsB; PqsC; PqsD; PqsE		PubMed 14739337				?								induced the expression of genes that are also activated by PQS, HHQ is converted by other cells than the producing into PQS	PubMed 14739337
Wolinella succinogenes	Bacteria	Proteobacteria	Epsilonproteobacteria	Campylobacterales	Helicobacteraceae	Wolinella	succinogenes		DSM 1740	AI-2	AI-2	446576	?				Yes?		proposed	PubMed 24611121												LuxS		PubMed 24611121	Q7MQP3.1	70	QEH48503.1	?
Yersinia enterocolitica	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	enterocolitica		NCTC 10460	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?				Yes		Experimental	PubMed 7494483												YenI		PubMed 7494483	X76082.1	27	NP_250123.1	YenR	proposed	PubMed 7494483	X76082.1	44	AAN52499.1	cytoplasm	PubMed 11700290
Yersinia enterocolitica	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	enterocolitica		NCTC 10460	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes?				Yes		Experimental	PubMed 7494483												YenI		PubMed 7494483	X76082.1	27	NP_250123.1	YenR	proposed	PubMed 7494483	X76082.1	44	AAN52499.1	cytoplasm	PubMed 11700290
Yersinia enterocolitica	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	enterocolitica		JB580	AI-2	AI-2	446576	?				Yes		no mutant	PubMed 9190823												LuxS		PubMed 9190823	AJJ22408.1	74	QEH48503.1	?
Yersinia enterocolitica	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	enterocolitica		JB580	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Inhibit			PubMed 21362062	Yes		Experimental	PubMed 21362062												YenI		PubMed 21362062	CAA53693.1	27	NP_250123.1	YenR	proposed	PubMed 21362062	CAA53694.1	44	AAN52499.1	cytoplasm	PubMed 11700290	regulated swarming motility	PubMed 21362062
Yersinia frederiksenii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	frederiksenii		ATCC 33641	AI-2	AI-2	446576	Yes?				?															?						LsrB	proposed	PubMed 22778662	no entry
Yersinia frederiksenii	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	frederiksenii		ATCC 33641	Indole	indole	798	?				Yes		no mutant	PubMed 10865195												?						?
Yersinia intermedia	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	intermedia		ATCC 29909	Indole	indole	798	?				Yes		no mutant	PubMed 10865195												?						?
Yersinia pestis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pestis		CO92	AI-2	AI-2	446576	Yes?				Yes		Experimental	PubMed 23959719												LuxS		PubMed 23959719	CAL21891.1	75	QEH48503.1	LsrB	proposed	PubMed 23959719	AJJ87739.1	23	AYO33928.1	periplasm	PubMed 22139152	increased evasion of oxidative stress	PubMed 23959719
Yersinia pseudotuberculosis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pseudotuberculosis		III (pIB1)NalR (YpIII)	N-Acyl homoserine lactone	C6-HSL	10058590	Yes?			PubMed 10510240	Yes		Experimental	PubMed 10510240												YtbI		PubMed 10510240	AF079136.2	44	X76082.1	YtbR	proposed	PubMed 10510240	AF079136.2	54	AAN52499.1	cytoplasm	PubMed 11700290
Yersinia pseudotuberculosis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pseudotuberculosis		III (pIB1)NalR (YpIII)	N-Acyl homoserine lactone	C8-HSL	6914579	Yes?			PubMed 10510240	Yes		Experimental	PubMed 10510240												YtbI		PubMed 10510240	AF079136.2	44	X76082.1	YtbR	proposed	PubMed 10510240	AF079136.2	54	AAN52499.1	cytoplasm	PubMed 11700290
Yersinia pseudotuberculosis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pseudotuberculosis		III (pIB1)NalR (YpIII)	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes?			PubMed 10510240	Yes		Experimental	PubMed 10510240												YtbI		PubMed 10510240	AF079136.2	44	X76082.1	YtbR	proposed	PubMed 10510240	AF079136.2	54	AAN52499.1	cytoplasm	PubMed 11700290
Yersinia pseudotuberculosis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pseudotuberculosis		III (pIB1)NalR (YpIII)	N-Acyl homoserine lactone	C6-HSL	10058590	Yes		Experimental	PubMed 10510240	Yes		Experimental	PubMed 10510240												YpsI		PubMed 10510240	AF079973.1	46	X76082.1	YpsR	knockout mutants produced less AHL	PubMed 10510240	AF079973.1	54	AAN52499.1	cytoplasm	PubMed 11700290	regulation of motility	PubMed 10510240
Yersinia pseudotuberculosis	Bacteria	Proteobacteria	Gammaproteobacteria	Enterobacteriales	Enterobacteriaceae	Yersinia	pseudotuberculosis		III (pIB1)NalR (YpIII)	N-Acyl homoserine lactone	3-oxo-C6-HSL	688505	Yes		Experimental	PubMed 10510240	Yes		Experimental	PubMed 10510240												YpsI		PubMed 10510240	AF079973.1	46	X76082.1	YpsR	knockout mutants produced less AHL	PubMed 10510240	AF079973.1	54	AAN52499.1	cytoplasm	PubMed 11700290	regulation of motility	PubMed 10510240